| 1 | AEP to BOG Bogota, Colombia | 2,900 mi | 6h 34m | Avianca and Aerolineas Argentinas | 1-2/day |
| 2 | AEP to FOR Fortaleza, Brazil | 2,480 mi | 5h 42m | GOL Airlines | 2×/wk |
| 3 | AEP to NAT São Gonçalo do Amarante, Brazil | 2,474 mi | 5h 41m | JetSMART and GOL Airlines | 4×/wk |
| 4 | AEP to REC Recife, Brazil | 2,357 mi | 5h 27m | JetSMART and GOL Airlines | 4×/wk |
| 5 | AEP to MCZ Maceio, Brazil | 2,245 mi | 5h 13m | GOL Airlines | weekly |
| 6 | AEP to SSA Salvador, Brazil | 1,954 mi | 4h 37m | GOL Airlines | weekly |
| 7 | AEP to LIM Lima, Peru | 1,950 mi | 4h 36m | LATAM Peru, Aerolineas Argentinas, and JAP | 4-5/day |
| 8 | AEP to BPS Porto Seguro, Brazil | 1,732 mi | 4h 9m | GOL Airlines | weekly |
| 9 | AEP to USH Ushuahia, Argentina | 1,480 mi | 3h 38m | Aerolineas Argentinas and JetSMART | 3-4/day |
| 10 | AEP to BSB Brasilia, Brazil | 1,446 mi | 3h 34m | GOL Airlines | 1/day |
| 11 | AEP to RGA Rio Grande, Argentina | 1,403 mi | 3h 29m | Aerolineas Argentinas | 1/day |
| 12 | AEP to CNF Belo Horizonte, Brazil | 1,358 mi | 3h 23m | GOL Airlines | weekly |
| 13 | AEP to RGL Rio Gallegos, Argentina | 1,297 mi | 3h 16m | Aerolineas Argentinas | 1/day |
| 14 | AEP to FTE El Calafate, Argentina | 1,285 mi | 3h 14m | Aerolineas Argentinas | 1-2/day |
| 15 | AEP to GIG Rio de Janeiro, Brazil | 1,224 mi | 3h 6m | Aerolineas Argentinas, GOL Airlines, and JetSMART | 7-8/day |
| 16 | AEP to VVI Santa Cruz, Bolivia | 1,204 mi | 3h 4m | Aerolineas Argentinas | 2×/wk |
| 17 | AEP to GRU Sao Paulo, Brazil | 1,053 mi | 2h 45m | LATAM Airlines, GOL Airlines, and Aerolineas Argentinas | 12-13/day |
| 18 | AEP to CRD Comodoro Rivadavia, Argentina | 910 mi | 2h 28m | Aerolineas Argentinas and JetSMART | 4-5/day |
| 19 | AEP to EQS Esquel, Argentina | 894 mi | 2h 26m | Aerolineas Argentinas | 2×/wk |
| 20 | AEP to CWB Curitiba, Brazil | 833 mi | 2h 18m | Aerolineas Argentinas | 1/day |
| 21 | AEP to BRC Bariloche, Argentina | 830 mi | 2h 18m | Aerolineas Argentinas, JetSMART, and Flybondi | 7-8/day |
| 22 | AEP to JUJ San Salvador de Jujuy, Argentina | 809 mi | 2h 15m | Aerolineas Argentinas and Flybondi | 2-3/day |
| 23 | AEP to CPC Chapelco/San Martin de los Andes, Argentina | 795 mi | 2h 13m | Aerolineas Argentinas and JetSMART | 1-2/day |
| 24 | AEP to SLA Salta, Argentina | 793 mi | 2h 13m | Aerolineas Argentinas, JetSMART, and Flybondi | 5-6/day |
| 25 | AEP to FLN Florianopolis, Brazil | 752 mi | 2h 8m | GOL Airlines | 1/day |