| 1 | CTG to AMS Amsterdam, Netherlands | 5,239 mi | 11h 24m | KLM | 3×/wk |
| 2 | CTG to YUL Montreal, Canada | 2,422 mi | 5h 35m | Air Transat | weekly |
| 3 | CTG to YYZ Toronto, Canada | 2,310 mi | 5h 21m | Air Transat | weekly |
| 4 | CTG to JFK New York, United States | 2,089 mi | 4h 54m | JetBlue Airways | 1/day |
| 5 | CTG to ATL Atlanta, United States | 1,699 mi | 4h 5m | Delta Air Lines | 3×/wk |
| 6 | CTG to NLU Reyes Acozac, Mexico | 1,692 mi | 4h 4m | VivaAerobus | 3×/wk |
| 7 | CTG to MEX Mexico City, Mexico | 1,689 mi | 4h 4m | Aeromexico | 1/day |
| 8 | CTG to FLL Fort Lauderdale, United States | 1,122 mi | 2h 54m | JetBlue Airways | 1/day |
| 9 | CTG to MIA Miami, United States | 1,106 mi | 2h 52m | American Airlines | 2/day |
| 10 | CTG to SDQ Santo Domingo, Dominican Republic | 676 mi | 1h 59m | Arajet | 2×/wk |
| 11 | CTG to SJO San Jose, Costa Rica | 592 mi | 1h 48m | Avianca | 1/day |
| 12 | CTG to CLO Cali, Colombia | 480 mi | 1h 34m | JetSMART, Avianca, and LATAM | 3-4/day |
| 13 | CTG to ADZ San Andres, Colombia | 445 mi | 1h 30m | LATAM and Copa Colombia | 3-4/day |
| 14 | CTG to BOG Bogota, Colombia | 408 mi | 1h 25m | Avianca, LATAM, and JetSMART | 29-30/day |
| 15 | CTG to PEI Pereira, Colombia | 389 mi | 1h 23m | Avianca and JetSMART | 2/day |
| 16 | CTG to BLB Panama City, Panama | 298 mi | 1h 12m | Copa Colombia | 2×/wk |
| 17 | CTG to MDE Medellin, Colombia | 296 mi | 1h 12m | Avianca, JetSMART, and Copa Colombia | 14-15/day |
| 18 | CTG to PTY Panama City, Panama | 280 mi | 1h 10m | Copa | 4/day |
| 19 | CTG to BGA Bucaramanga, Colombia | 279 mi | 1h 10m | Avianca and Copa Colombia | 1-2/day |