| Mexico City (MEX) Licenciado Benito Juarez International Airport | Mexico | 798 mi | 2h 14m | Aeromexico, VivaAerobus, and Volaris | 24-25/day |
| Monterrey (MTY) General Mariano Escobedo International Airport | Mexico | 900 mi | 2h 26m | VivaAerobus and Volaris | 10-11/day |
| Dallas (DFW) Dallas-Fort Worth International Airport | United States | 1,030 mi | 2h 42m | American Airlines, Sun Country Airlines, and Frontier Airlines | 9-10/day |
| Toronto (YYZ) Toronto Pearson International Airport | Canada | 1,619 mi | 3h 55m | WestJet, Air Canada, and Air Transat | 7/day |
| Houston (IAH) George Bush Intcntl/Houston Airport | United States | 812 mi | 2h 16m | United Airlines and Frontier Airlines | 7/day |
| Reyes Acozac (NLU) Santa Lucia Air Force Base | Mexico | 791 mi | 2h 13m | VivaAerobus, Aeromexico, and Volaris | 7/day |
| Atlanta (ATL) Hartsfield/Jackson Atlanta International Airport | United States | 883 mi | 2h 24m | Delta Air Lines, Frontier Airlines, and Southwest Airlines | 6-7/day |
| Guadalajara (GDL) Don Miguel Hidalgo Y Costilla International Airport | Mexico | 1,062 mi | 2h 46m | Volaris and VivaAerobus | 6-7/day |
| Panama City (PTY) Tocumen International Airport | Panama | 966 mi | 2h 35m | Copa | 5-6/day |
| Chicago (ORD) Chicago O'Hare International Airport | United States | 1,448 mi | 3h 34m | United Airlines, American Airlines, and Frontier Airlines | 5-6/day |
| Denver (DEN) Denver International Airport | United States | 1,671 mi | 4h 2m | United Airlines, Southwest Airlines, and Frontier Airlines | 5-6/day |
| Los Angeles (LAX) Los Angeles International Airport | United States | 2,117 mi | 4h 57m | United Airlines, American Airlines, and Delta Air Lines | 4-5/day |
| New York (JFK) John F Kennedy International Airport | United States | 1,557 mi | 3h 48m | JetBlue Airways, American Airlines, and Delta Air Lines | 4-5/day |
| Newark (EWR) Newark Liberty International Airport | United States | 1,549 mi | 3h 47m | United Airlines and JetBlue Airways | 4/day |
| Charlotte (CLT) Charlotte/Douglas International Airport | United States | 1,043 mi | 2h 44m | American Airlines | 4/day |
| Toluca (TLC) Licenciado Adolfo Lopez Mateos International Airport | Mexico | 831 mi | 2h 18m | VivaAerobus and Volaris | 4/day |
| Miami (MIA) Miami International Airport | United States | 531 mi | 1h 41m | American Airlines | 3-4/day |
| Houston (HOU) William P Hobby Airport | United States | 792 mi | 2h 13m | Southwest Airlines | 3-4/day |
| St. Louis (STL) St Louis Lambert International Airport | United States | 1,241 mi | 3h 9m | Southwest Airlines and Frontier Airlines | 3-4/day |
| Montreal (YUL) Montréal-Pierre Elliott Trudeau International Airport | Canada | 1,845 mi | 4h 23m | Air Canada, Air Transat, and WestJet | 3/day |
| Philadelphia (PHL) Philadelphia International Airport | United States | 1,471 mi | 3h 37m | American Airlines and Frontier Airlines | 2-3/day |
| Silao (BJX) Del Bajio International Airport | Mexico | 942 mi | 2h 32m | Volaris and VivaAerobus | 2-3/day |
| Austin (AUS) Austin-Bergstrom International Airport | United States | 922 mi | 2h 29m | Southwest Airlines and American Airlines | 2-3/day |
| Puebla (PBC) Hermanos Serdan International Airport | Mexico | 757 mi | 2h 9m | Volaris and VivaAerobus | 2-3/day |
| Orlando (MCO) Orlando International Airport | United States | 619 mi | 1h 52m | JetBlue Airways and Southwest Airlines | 2-3/day |
| Baltimore (BWI) Baltimore/Washington International Thurgood Marshall Airport | United States | 1,392 mi | 3h 27m | Southwest Airlines | 2-3/day |
| Queretaro (QRO) Queretaro Intercontinental Airport | Mexico | 860 mi | 2h 21m | Volaris and VivaAerobus | 2-3/day |
| San Francisco (SFO) San Francisco International Airport | United States | 2,405 mi | 5h 33m | United Airlines | 2-3/day |
| Tijuana (TIJ) General Abelardo L. Rodriguez International Airport | Mexico | 2,010 mi | 4h 44m | Volaris and VivaAerobus | 2-3/day |
| Phoenix (PHX) Phoenix Sky Harbor International Airport | United States | 1,759 mi | 4h 13m | Southwest Airlines and American Airlines | 2-3/day |
| Boston (BOS) General Edward Lawrence Logan International Airport | United States | 1,737 mi | 4h 10m | Delta Air Lines and JetBlue Airways | 2/day |
| Detroit (DTW) Detroit Metro Wayne County Airport | United States | 1,477 mi | 3h 38m | Delta Air Lines | 2/day |
| Washington (IAD) Washington Dulles International Airport | United States | 1,358 mi | 3h 23m | United Airlines | 2/day |
| Veracruz (VER) General Heriberto Jara International Airport | Mexico | 618 mi | 1h 52m | VivaAerobus | 2/day |
| Fort Lauderdale (FLL) Fort Lauderdale/Hollywood International Airport | United States | 550 mi | 1h 43m | JetBlue Airways | 2/day |
| San Antonio (SAT) San Antonio International Airport | United States | 931 mi | 2h 30m | Southwest Airlines and Sun Country Airlines | 1-2/day |
| Tuxtla Gutierrez (TGZ) Angel Albino Corzo International Airport | Mexico | 507 mi | 1h 38m | Volaris and VivaAerobus | 1-2/day |
| Chicago (MDW) Chicago Midway International Airport | United States | 1,435 mi | 3h 33m | Southwest Airlines | 1-2/day |
| New Orleans (MSY) Louis Armstrong New Orleans International Airport | United States | 654 mi | 1h 56m | Southwest Airlines and Breeze | 1-2/day |
| Minneapolis (MSP) Minneapolis-St Paul International/Wold-Chamberlain Airport | United States | 1,687 mi | 4h 4m | Delta Air Lines and Sun Country Airlines | 1-2/day |
| Kansas City (MCI) Kansas City International Airport | United States | 1,344 mi | 3h 21m | Southwest Airlines | 1-2/day |
| Punta Cana (PUJ) Punta Cana International Airport | Dominican Republic | 1,215 mi | 3h 5m | Arajet and Aerolineas Argentinas | 1-2/day |
| Nashville (BNA) Nashville International Airport | United States | 1,043 mi | 2h 44m | Southwest Airlines | 1-2/day |
| Calgary (YYC) Calgary International Airport | Canada | 2,542 mi | 5h 50m | WestJet | 1-2/day |
| Cleveland (CLE) Cleveland-Hopkins International Airport | United States | 1,438 mi | 3h 33m | Frontier Airlines and United Airlines | 1-2/day |
| Guatemala City (GUA) La Aurora Airport | Guatemala | 506 mi | 1h 38m | Volaris and Avianca | 1-2/day |
| Salt Lake City (SLC) Salt Lake City International Airport | United States | 2,005 mi | 4h 43m | Delta Air Lines | 1/day |
| Ciudad Juarez (CJS) Abraham Gonzalez International Airport | Mexico | 1,411 mi | 3h 30m | VivaAerobus | 1/day |
| Chihuahua (CUU) General Roberto Fierro Villalobos International Airport | Mexico | 1,306 mi | 3h 17m | VivaAerobus | 1/day |
| San Luis Potosi (SLP) Ponciano Arriaga International Airport | Mexico | 906 mi | 2h 27m | Volaris | 1/day |
| San Jose (SJO) Juan Santamaria International Airport | Costa Rica | 783 mi | 2h 12m | Volaris Costa Rica and Volaris | 1/day |
| Oaxaca (OAX) Xoxocotlan International Airport | Mexico | 701 mi | 2h 2m | Volaris | 1/day |
| Tampa (TPA) Tampa International Airport | United States | 552 mi | 1h 43m | JetBlue Airways | 1/day |
| Villahermosa (VSA) Carlos Rovirosa Perez International Airport | Mexico | 440 mi | 1h 29m | VivaAerobus | 1/day |
| Havana (HAV) Jose Marti International Airport | Cuba | 316 mi | 1h 14m | VivaAerobus | 1/day |
| Vancouver (YVR) Vancouver International Airport | Canada | 2,781 mi | 6h 19m | WestJet and Air Canada | 1/day |
| Las Vegas (LAS) Harry Reid International Airport | United States | 1,995 mi | 4h 42m | Southwest Airlines | 1/day |
| Columbus (CMH) John Glenn Columbus International Airport | United States | 1,331 mi | 3h 20m | Southwest Airlines | 1/day |
| Indianapolis (IND) Indianapolis International Airport | United States | 1,291 mi | 3h 15m | Southwest Airlines and American Airlines | 3×/wk |
| Cincinnati (CVG) Cincinnati/Northern Kentucky International Airport | United States | 1,251 mi | 3h 10m | VivaAerobus and Frontier Airlines | 3×/wk |
| Aguascalientes (AGU) Jesus Teran International Airport | Mexico | 994 mi | 2h 38m | Volaris | 3×/wk |
| Morelia (MLM) General Francisco J. Mujica International Airport | Mexico | 919 mi | 2h 29m | Volaris | 3×/wk |
| Reynosa (REX) General Lucio Blanco International Airport | Mexico | 796 mi | 2h 14m | VivaAerobus | 3×/wk |
| Tampico (TAM) General Francisco Javier Mina International Airport | Mexico | 711 mi | 2h 3m | VivaAerobus | 3×/wk |
| Edmonton (YEG) Edmonton International Airport | Canada | 2,638 mi | 6h 2m | WestJet | 2×/wk |
| Quebec City (YQB) Québec City Jean Lesage International Airport | Canada | 1,980 mi | 4h 40m | Air Transat and WestJet | weekly |
| Ottawa (YOW) Ottawa / Macdonald-Cartier International Airport | Canada | 1,795 mi | 4h 17m | Porter | 2×/wk |
| Pittsburgh (PIT) Pittsburgh International Airport | United States | 1,400 mi | 3h 28m | Allegiant Air and Southwest Airlines | weekly |
| Tulsa (TUL) Tulsa International Airport | United States | 1,180 mi | 3h 1m | Sun Country Airlines | 2×/wk |
| Torreon (TRC) Francisco Sarabia International Airport | Mexico | 1,094 mi | 2h 50m | VivaAerobus | 2×/wk |
| Harlingen (HRL) Valley International Airport | United States | 770 mi | 2h 10m | Sun Country Airlines | 2×/wk |
| Winnipeg (YWG) Winnipeg James Armstrong Richardson International Airport | Canada | 2,074 mi | 4h 52m | WestJet | weekly |
| San Jose del Cabo (SJD) Los Cabos International Airport | Mexico | 1,468 mi | 3h 37m | VivaAerobus | weekly |
| Norfolk (ORF) Norfolk International Airport | United States | 1,269 mi | 3h 12m | Breeze | weekly |
| Charleston (CHS) Charleston Afb/International Airport | United States | 921 mi | 2h 29m | Breeze | weekly |
| Camaguey (CMW) Ignacio Agramonte International Airport | Cuba | 582 mi | 1h 47m | VivaAerobus | weekly |
| Santa Clara (SAL) El Salvador International Airport | El Salvador | 544 mi | 1h 42m | Avianca | weekly |