| 1 | CUR to AMS Amsterdam, Netherlands | 4,868 mi | ~10h 38m | TUI Nederland (Netherlands), KLM, and Corendon Dutch | 3/day |
| 2 | CUR to YYZ Toronto, Canada | 2,267 mi | ~5h 16m | Air Canada | 2×/wk |
| 3 | CUR to IAH Houston, United States | 2,089 mi | ~4h 54m | Corendon Dutch | 5×/wk |
| 4 | CUR to EWR Newark, United States | 1,995 mi | ~4h 42m | United Airlines | weekly |
| 5 | CUR to JFK New York, United States | 1,987 mi | ~4h 41m | JetBlue Airways | 1/day |
| 6 | CUR to ATL Atlanta, United States | 1,774 mi | ~4h 15m | Delta Air Lines | 3×/wk |
| 7 | CUR to CLT Charlotte, United States | 1,759 mi | ~4h 13m | American Airlines | weekly |
| 8 | CUR to PBI West Palm Beach, United States | 1,235 mi | ~3h 8m | Corendon Dutch | weekly |
| 9 | CUR to MIA Miami, United States | 1,195 mi | ~3h 3m | American Airlines, GlobalX, and Surinam | 2-3/day |
| 10 | CUR to PBM Zandery, Suriname | 1,049 mi | ~2h 45m | Surinam | 2×/wk |
| 11 | CUR to PTY Panama City, Panama | 740 mi | ~2h 7m | Copa | 2-3/day |
| 12 | CUR to BOG Bogota, Colombia | 627 mi | ~1h 53m | Avianca | 2/day |
| 13 | CUR to MDE Medellin, Colombia | 606 mi | ~1h 50m | Copa Colombia | 2×/wk |
| 14 | CUR to SXM Saint Martin, Sint Maarten | 562 mi | ~1h 45m | Winair | 1-2/day |
| 15 | CUR to POS Port of Spain, Trinidad & Tobago | 528 mi | ~1h 40m | Caribbean | 2×/wk |
| 16 | CUR to SDQ Santo Domingo, Dominican Republic | 434 mi | ~1h 29m | Arajet | 2×/wk |
| 17 | CUR to CCS Caracas, Venezuela | 173 mi | ~56m | Avior and LASER | 3×/wk |
| 18 | CUR to AUA Oranjestad, Aruba | 74 mi | ~44m | Divi Divi Air, Winair, and Surinam | 8-9/day |
| 19 | CUR to BON Kralendijk, Caribbean Netherlands | 47 mi | ~41m | Divi Divi Air, Winair, and TUI Nederland (Netherlands) | 7-8/day |