| 1 | FLL to VCP Campinas, Brazil | 4,047 mi | 8h 56m | Azul Airlines | 1/day |
| 2 | FLL to BEL Belem, Brazil | 2,839 mi | 6h 26m | Azul Airlines | weekly |
| 3 | FLL to SEA Seattle, United States | 2,714 mi | 6h 11m | Alaska Airlines and Delta Air Lines | 2/day |
| 4 | FLL to SFO San Francisco, United States | 2,579 mi | 5h 54m | JetBlue Airways and United Airlines | 3/day |
| 5 | FLL to VNY Van Nuys, United States | 2,344 mi | 5h 25m | Vuela El Salvador | weekly |
| 6 | FLL to LAX Los Angeles, United States | 2,339 mi | 5h 25m | JetBlue Airways, Delta Air Lines, and United Airlines | 6-7/day |
| 7 | FLL to LAS Las Vegas, United States | 2,170 mi | 5h 4m | JetBlue Airways | 2/day |
| 8 | FLL to SLC Salt Lake City, United States | 2,081 mi | 4h 53m | Delta Air Lines | 1/day |
| 9 | FLL to PHX Phoenix, United States | 1,969 mi | 4h 39m | American Airlines | 1/day |
| 10 | FLL to GYE Guayaquil, Ecuador | 1,951 mi | 4h 36m | JetBlue Airways | 1/day |
| 11 | FLL to DEN Denver, United States | 1,702 mi | 4h 6m | United Airlines and Southwest Airlines | 3-4/day |
| 12 | FLL to POS Port of Spain, Trinidad & Tobago | 1,629 mi | 3h 57m | Caribbean | 1/day |
| 13 | FLL to BOG Bogota, Colombia | 1,529 mi | 3h 44m | Avianca | 2/day |
| 14 | FLL to MSP Minneapolis, United States | 1,489 mi | 3h 39m | Delta Air Lines | 1/day |
| 15 | FLL to MDE Medellin, Colombia | 1,410 mi | 3h 30m | Avianca and JetBlue Airways | 1-2/day |
| 16 | FLL to YUL Montreal, Canada | 1,386 mi | 3h 27m | Air Canada and Air Transat | 2/day |
| 17 | FLL to YOW Ottawa, Canada | 1,353 mi | 3h 23m | Porter | 2×/wk |
| 18 | FLL to ATW Appleton, United States | 1,341 mi | 3h 21m | Allegiant Air | 2×/wk |
| 19 | FLL to PBG Plattsburgh, United States | 1,337 mi | 3h 20m | Allegiant Air | 2×/wk |
| 20 | FLL to DSM Des Moines, United States | 1,317 mi | 3h 18m | Allegiant Air | 2×/wk |
| 21 | FLL to CID Cedar Rapids, United States | 1,275 mi | 3h 13m | Allegiant Air | 2×/wk |
| 22 | FLL to MCI Kansas City, United States | 1,243 mi | 3h 9m | Southwest Airlines | 1-2/day |
| 23 | FLL to BOS Boston, United States | 1,239 mi | 3h 8m | JetBlue Airways and Delta Air Lines | 5-6/day |
| 24 | FLL to RFD Chicago/Rockford, United States | 1,224 mi | 3h 7m | Allegiant Air | 2×/wk |
| 25 | FLL to SXM Saint Martin, Sint Maarten | 1,223 mi | 3h 6m | JetBlue Airways | 1/day |