| 1 | GRR to PVG Shanghai, China | 7,037 mi | ~15h 6m | Delta Air Lines | weekly |
| 2 | GRR to SNA Santa Ana, United States | 1,852 mi | ~4h 24m | Allegiant Air | 2×/wk |
| 3 | GRR to PDX Portland, United States | 1,828 mi | ~4h 21m | Allegiant Air | 2×/wk |
| 4 | GRR to LAS Las Vegas, United States | 1,639 mi | ~3h 58m | Allegiant Air and Southwest Airlines | 1/day |
| 5 | GRR to AZA Phoenix, United States | 1,559 mi | ~3h 48m | Allegiant Air | 1/day |
| 6 | GRR to NAS Nassau, Bahamas | 1,315 mi | ~3h 18m | Saga Airlines | weekly |
| 7 | GRR to JAC Jackson, United States | 1,265 mi | ~3h 12m | United Airlines | weekly |
| 8 | GRR to MIA Miami, United States | 1,217 mi | ~3h 6m | American Airlines | 2×/wk |
| 9 | GRR to FLL Fort Lauderdale, United States | 1,200 mi | ~3h 4m | Allegiant Air | 2×/wk |
| 10 | GRR to PGD Punta Gorda, United States | 1,121 mi | ~2h 54m | Allegiant Air | 3×/wk |
| 11 | GRR to AUS Austin, United States | 1,103 mi | ~2h 52m | Allegiant Air | 2×/wk |
| 12 | GRR to SRQ Sarasota/Bradenton, United States | 1,083 mi | ~2h 49m | Allegiant Air | 2×/wk |
| 13 | GRR to PIE St Petersburg-Clearwater, United States | 1,047 mi | ~2h 45m | Allegiant Air | 1/day |
| 14 | GRR to IAH Houston, United States | 1,043 mi | ~2h 44m | United Airlines | 1-2/day |
| 15 | GRR to MCO Orlando, United States | 1,026 mi | ~2h 42m | Frontier Airlines | 3×/wk |
| 16 | GRR to DEN Denver, United States | 1,012 mi | ~2h 40m | United Airlines, Southwest Airlines, and Frontier Airlines | 4-5/day |
| 17 | GRR to SFB Orlando, United States | 1,003 mi | ~2h 39m | Allegiant Air | 1/day |
| 18 | GRR to DFW Dallas, United States | 931 mi | ~2h 30m | American Airlines | 2-3/day |
| 19 | GRR to JAX Jacksonville, United States | 882 mi | ~2h 24m | Allegiant Air | 2×/wk |
| 20 | GRR to BOS Boston, United States | 738 mi | ~2h 6m | Allegiant Air | 2×/wk |
| 21 | GRR to ATL Atlanta, United States | 641 mi | ~1h 54m | Delta Air Lines | 3-4/day |
| 22 | GRR to LGA New York, United States | 617 mi | ~1h 51m | Delta Air Lines and American Airlines | 3-4/day |
| 23 | GRR to EWR Newark, United States | 604 mi | ~1h 50m | United Airlines | 2-3/day |
| 24 | GRR to CLT Charlotte, United States | 584 mi | ~1h 47m | American Airlines | 3/day |
| 25 | GRR to PHL Philadelphia, United States | 572 mi | ~1h 46m | American Airlines and Allegiant Air | 2-3/day |