| 1 | IND to HKG Hong Kong, Hong Kong SAR China | 7,957 mi | 17h | Cathay Pacific | weekly |
| 2 | IND to DUB Dublin, Ireland | 3,708 mi | 8h 14m | Aer Lingus | 1/day |
| 3 | IND to SFO San Francisco, United States | 1,939 mi | 4h 35m | United Airlines | 1-2/day |
| 4 | IND to SJU San Juan, United States | 1,904 mi | 4h 31m | Southwest Airlines | weekly |
| 5 | IND to PDX Portland, United States | 1,872 mi | 4h 27m | Allegiant Air | 2×/wk |
| 6 | IND to SEA Seattle, United States | 1,861 mi | 4h 25m | Alaska Airlines | 2/day |
| 7 | IND to LAX Los Angeles, United States | 1,810 mi | 4h 19m | American Airlines and Delta Air Lines | 2-3/day |
| 8 | IND to BUR Burbank, United States | 1,801 mi | 4h 18m | Allegiant Air | 2×/wk |
| 9 | IND to SAN San Diego, United States | 1,778 mi | 4h 15m | Southwest Airlines | 1/day |
| 10 | IND to LAS Las Vegas, United States | 1,586 mi | 3h 51m | Southwest Airlines and Allegiant Air | 4-5/day |
| 11 | IND to PHX Phoenix, United States | 1,486 mi | 3h 39m | Southwest Airlines and American Airlines | 4-5/day |
| 12 | IND to SLC Salt Lake City, United States | 1,352 mi | 3h 22m | Delta Air Lines | 1/day |
| 13 | IND to CUN Cancun, Mexico | 1,291 mi | 3h 15m | Southwest Airlines | 2×/wk |
| 14 | IND to LRD Laredo, United States | 1,129 mi | 2h 55m | BYA | weekly |
| 15 | IND to EYW Key West, United States | 1,080 mi | 2h 49m | Allegiant Air | 2×/wk |
| 16 | IND to MIA Miami, United States | 1,023 mi | 2h 42m | American Airlines and Southwest Airlines | 2-3/day |
| 17 | IND to FLL Fort Lauderdale, United States | 1,007 mi | 2h 40m | Southwest Airlines and Allegiant Air | 2-3/day |
| 18 | IND to DEN Denver, United States | 974 mi | 2h 36m | Southwest Airlines, United Airlines, and Frontier Airlines | 8-9/day |
| 19 | IND to RSW Fort Myers, United States | 947 mi | 2h 32m | Southwest Airlines | 1-2/day |
| 20 | IND to AUS Austin, United States | 919 mi | 2h 29m | Southwest Airlines and Delta Air Lines | 6/day |
| 21 | IND to PGD Punta Gorda, United States | 918 mi | 2h 29m | Allegiant Air | 1/day |
| 22 | IND to SRQ Sarasota/Bradenton, United States | 878 mi | 2h 24m | Allegiant Air and Southwest Airlines | 5×/wk |
| 23 | IND to HOU Houston, United States | 862 mi | 2h 22m | Southwest Airlines | 1-2/day |
| 24 | IND to IAH Houston, United States | 845 mi | 2h 20m | United Airlines | 3-4/day |
| 25 | IND to PIE St Petersburg-Clearwater, United States | 842 mi | 2h 19m | Allegiant Air | 1/day |