| 1 | ISP to RSW Fort Myers, United States | 1,102 mi | 2h 51m | Breeze | 3×/wk |
| 2 | ISP to FLL Fort Lauderdale, United States | 1,095 mi | 2h 51m | JetBlue Airways | 1-2/day |
| 3 | ISP to PBI West Palm Beach, United States | 1,054 mi | 2h 45m | JetBlue Airways and Southwest Airlines | 2-3/day |
| 4 | ISP to TPA Tampa, United States | 1,035 mi | 2h 43m | Frontier Airlines and Southwest Airlines | 1/day |
| 5 | ISP to VRB Vero Beach, United States | 999 mi | 2h 39m | Breeze | 2×/wk |
| 6 | ISP to MCO Orlando, United States | 973 mi | 2h 35m | Southwest Airlines, JetBlue Airways, and Frontier Airlines | 3-4/day |
| 7 | ISP to CHS Charleston, United States | 667 mi | 1h 58m | Breeze | 1/day |
| 8 | ISP to MYR Myrtle Beach, United States | 587 mi | 1h 48m | Frontier Airlines and Breeze | 1/day |
| 9 | ISP to ILM Wilmington, United States | 522 mi | 1h 40m | Breeze | 3×/wk |
| 10 | ISP to ZZV Zanesville, United States | 466 mi | 1h 33m | ARF | weekly |
| 11 | ISP to RDU Raleigh, United States | 459 mi | 1h 32m | Breeze | 1/day |
| 12 | ISP to RIC Richmond, United States | 321 mi | 1h 15m | Breeze | 2×/wk |
| 13 | ISP to ORF Norfolk, United States | 317 mi | 1h 14m | Breeze | 3×/wk |
| 14 | ISP to BWI Baltimore, United States | 220 mi | 1h 2m | Southwest Airlines | 5-6/day |
| 15 | ISP to HYA Hyannis, United States | 158 mi | 55m | United Airlines | 2×/wk |
| 16 | ISP to BOS Boston, United States | 153 mi | 54m | United Airlines | 3-4/day |
| 17 | ISP to RDG Reading, United States | 153 mi | 54m | ARF | weekly |
| 18 | ISP to JFK New York, United States | 37 mi | 40m | JetBlue Airways | weekly |
| 19 | ISP to FRG Farmingdale, United States | 17 mi | 37m | FDL | weekly |
| 20 | ISP to WSH Shirley, United States | 12 mi | 37m | FDL and CAP | weekly |