| 1 | KIX to YYZ Toronto, Canada | 6,611 mi | 14h 13m | Air Canada | 3×/wk |
| 2 | KIX to CDG Paris, France | 5,981 mi | 12h 55m | Air France | 1/day |
| 3 | KIX to AMS Amsterdam, Netherlands | 5,742 mi | 12h 26m | KLM | 2×/wk |
| 4 | KIX to MUC Munich, Germany | 5,741 mi | 12h 26m | Lufthansa | 1/day |
| 5 | KIX to LAX Los Angeles, United States | 5,730 mi | 12h 24m | Japan Airlines | 1/day |
| 6 | KIX to IST Istanbul, Türkiye | 5,433 mi | 11h 48m | Turkish Airlines | 1/day |
| 7 | KIX to SFO San Francisco, United States | 5,401 mi | 11h 44m | United Airlines | 1/day |
| 8 | KIX to YVR Vancouver, Canada | 4,930 mi | 10h 45m | Air Canada | 1/day |
| 9 | KIX to SYD Sydney, Australia | 4,835 mi | 10h 34m | Jetstar | 3×/wk |
| 10 | KIX to HEL Helsinki, Finland | 4,805 mi | 10h 30m | Finnair | 1/day |
| 11 | KIX to AUH Abu Dhabi, United Arab Emirates | 4,775 mi | 10h 26m | Etihad Airways | 2×/wk |
| 12 | KIX to DWC Jebel Ali, United Arab Emirates | 4,731 mi | 10h 21m | Emirates | 2×/wk |
| 13 | KIX to DXB Dubai, United Arab Emirates | 4,708 mi | 10h 18m | Emirates | 1/day |
| 14 | KIX to BNE Brisbane, Australia | 4,428 mi | 9h 43m | Jetstar | 1/day |
| 15 | KIX to HNL Honolulu, United States | 4,110 mi | 9h 4m | Alaska Airlines and Japan Airlines | 1-2/day |
| 16 | KIX to CNS Cairns, Australia | 3,612 mi | 8h 2m | Jetstar | 1/day |
| 17 | KIX to KUL Kuala Lumpur, Malaysia | 3,071 mi | 6h 55m | Malaysia Airlines, AirAsia X, and Malindo Air | 1-2/day |
| 18 | KIX to SIN Singapore, Singapore | 3,046 mi | 6h 52m | Singapore Airlines, Peach Aviation, and Scoot | 5/day |
| 19 | KIX to BKK Bangkok, Thailand | 2,585 mi | 5h 55m | Thai Airways, Japan Airlines, and Peach Aviation | 4-5/day |
| 20 | KIX to DMK Bangkok, Thailand | 2,582 mi | 5h 55m | Thai AirAsia X | 1/day |
| 21 | KIX to CNX Chiang Mai, Thailand | 2,471 mi | 5h 41m | Thai Vietjet Air | 3×/wk |
| 22 | KIX to SGN Ho Chi Minh City, Vietnam | 2,430 mi | 5h 36m | Vietnam and VietJetAir | 1-2/day |
| 23 | KIX to DAD Da Nang, Vietnam | 2,102 mi | 4h 55m | Vietnam | 1/day |
| 24 | KIX to HAN Hanoi, Vietnam | 2,006 mi | 4h 43m | VietJetAir and Vietnam | 2/day |
| 25 | KIX to CEB Lapu-Lapu City, Philippines | 1,812 mi | 4h 19m | Cebu Pacific Air and Philippine Airlines | 1/day |