| 1 | LHR to PER Perth, Australia | 9,015 mi | 19h 11m | Qantas | 1/day |
| 2 | LHR to SCL Santiago, Chile | 7,241 mi | 15h 31m | British Airways | 3×/wk |
| 3 | LHR to BWN Bandar Seri Begawan, Brunei | 7,010 mi | 15h 3m | Royal Brunei | 3×/wk |
| 4 | LHR to EZE Buenos Aires, Argentina | 6,920 mi | 14h 52m | British Airways | weekly |
| 5 | LHR to SIN Singapore, Singapore | 6,763 mi | 14h 32m | Singapore Airlines, British Airways, and Qantas | 6-7/day |
| 6 | LHR to KUL Kuala Lumpur, Malaysia | 6,590 mi | 14h 11m | Malaysia Airlines and British Airways | 3/day |
| 7 | LHR to SGN Ho Chi Minh City, Vietnam | 6,350 mi | 13h 41m | Vietnam | 2×/wk |
| 8 | LHR to TPE Taipei, Taiwan | 6,079 mi | 13h 8m | China | 1/day |
| 9 | LHR to CPT Cape Town, South Africa | 6,015 mi | 13h | British Airways | 1/day |
| 10 | LHR to HAK Haikou, China | 5,990 mi | 12h 57m | Hainan | weekly |
| 11 | LHR to HKG Hong Kong, Hong Kong SAR China | 5,984 mi | 12h 56m | Cathay Pacific and British Airways | 6/day |
| 12 | LHR to SZX Shenzhen, China | 5,962 mi | 12h 53m | Shenzhen | 1/day |
| 13 | LHR to HND Tokyo, Japan | 5,960 mi | 12h 53m | British Airways, Japan Airlines, and All Nippon Airways | 4-5/day |
| 14 | LHR to BKK Bangkok, Thailand | 5,951 mi | 12h 52m | Thai Airways and EVA Air | 3/day |
| 15 | LHR to CAN Guangzhou, China | 5,900 mi | 12h 45m | China Southern | 1/day |
| 16 | LHR to GRU Sao Paulo, Brazil | 5,878 mi | 12h 43m | British Airways, LATAM, and LATAM Airlines | 2-3/day |
| 17 | LHR to GIG Rio de Janeiro, Brazil | 5,750 mi | 12h 27m | British Airways | 1/day |
| 18 | LHR to PVG Shanghai, China | 5,742 mi | 12h 26m | British Airways and China Eastern | 2/day |
| 19 | LHR to HAN Hanoi, Vietnam | 5,740 mi | 12h 26m | Vietnam | 3×/wk |
| 20 | LHR to JNB Johannesburg, South Africa | 5,639 mi | 12h 13m | British Airways and Virgin Atlantic | 3/day |
| 21 | LHR to CSX Changsha, China | 5,626 mi | 12h 12m | Hainan | 2×/wk |
| 22 | LHR to MEX Mexico City, Mexico | 5,533 mi | 12h | Aeromexico and British Airways | 2/day |
| 23 | LHR to WUH Wuhan, China | 5,514 mi | 11h 58m | China Southern | 2×/wk |
| 24 | LHR to ICN Seoul, South Korea | 5,506 mi | 11h 57m | Asiana Airlines, Korean Air, and Virgin Atlantic | 2-3/day |
| 25 | LHR to NZY San Diego, United States | 5,475 mi | 11h 53m | British Airways | 2×/wk |