| 1 | MFR to DEN Denver, United States | 961 mi | ~2h 34m | United Airlines | 1-2/day |
| 2 | MFR to PHX Phoenix, United States | 854 mi | ~2h 21m | American Airlines and United Airlines | 4/day |
| 3 | MFR to MTJ Montrose, United States | 830 mi | ~2h 18m | United Airlines | weekly |
| 4 | MFR to SAN San Diego, United States | 735 mi | ~2h 6m | American Airlines and Alaska Airlines | 3×/wk |
| 5 | MFR to SNA Santa Ana, United States | 660 mi | ~1h 57m | Allegiant Air | 2×/wk |
| 6 | MFR to LAX Los Angeles, United States | 631 mi | ~1h 53m | Alaska Airlines and American Airlines | 1-2/day |
| 7 | MFR to LAS Las Vegas, United States | 599 mi | ~1h 49m | Allegiant Air | 1/day |
| 8 | MFR to SLC Salt Lake City, United States | 573 mi | ~1h 46m | Delta Air Lines | 2/day |
| 9 | MFR to SEA Seattle, United States | 352 mi | ~1h 19m | Delta Air Lines, Alaska Airlines, and American Airlines | 5-6/day |
| 10 | MFR to SFO San Francisco, United States | 330 mi | ~1h 16m | United Airlines | 3-4/day |
| 11 | MFR to PDX Portland, United States | 222 mi | ~1h 3m | Alaska Airlines and Empire Airlines | 4-5/day |
| 12 | MFR to EUG Eugene, United States | 122 mi | ~50m | Libyan Airlines | weekly |
| 13 | MFR to RBG Roseburg, United States | 65 mi | ~43m | Empire Airlines | weekly |