| 1 | MIA to DXB Dubai, United Arab Emirates | 7,833 mi | 16h 45m | Emirates | 1/day |
| 2 | MIA to DOH Doha, Qatar | 7,668 mi | 16h 24m | Qatar Airways | 1-2/day |
| 3 | MIA to TLV Tel Aviv, Israel | 6,592 mi | 14h 11m | El Al | 1/day |
| 4 | MIA to IST Istanbul, Türkiye | 5,956 mi | 12h 52m | Turkish Airlines | 2/day |
| 5 | MIA to WAW Warsaw, Poland | 5,276 mi | 11h 28m | LOT Polish Airlines | 1/day |
| 6 | MIA to FCO Rome, Italy | 5,176 mi | 11h 16m | ITA and American Airlines | 2-3/day |
| 7 | MIA to MXP Milan, Italy | 4,921 mi | 10h 44m | American Airlines | 1/day |
| 8 | MIA to ZRH Zurich, Switzerland | 4,875 mi | 10h 38m | Swiss International | 1/day |
| 9 | MIA to FRA Frankfurt, Germany | 4,823 mi | 10h 32m | Lufthansa | 1/day |
| 10 | MIA to MST Maastricht, Netherlands | 4,689 mi | 10h 15m | Turkish Airlines | 3×/wk |
| 11 | MIA to BCN Barcelona, Spain | 4,688 mi | 10h 15m | LVL and American Airlines | 2-3/day |
| 12 | MIA to LGG Liege, Belgium | 4,677 mi | 10h 14m | Ethiopian Airlines and Qatar Airways | 3×/wk |
| 13 | MIA to AMS Amsterdam, Netherlands | 4,625 mi | 10h 8m | KLM, Qatar Airways, and Emirates | 1/day |
| 14 | MIA to CDG Paris, France | 4,580 mi | 10h 2m | Air France | 2-3/day |
| 15 | MIA to ORY Paris, France | 4,576 mi | 10h 2m | French Bee | 3×/wk |
| 16 | MIA to EZE Buenos Aires, Argentina | 4,424 mi | 9h 43m | American Airlines, Aerolineas Argentinas, and LATAM | 4-5/day |
| 17 | MIA to LHR London, United Kingdom | 4,417 mi | 9h 42m | British Airways, Virgin Atlantic, and American Airlines | 4-5/day |
| 18 | MIA to MAD Madrid, Spain | 4,416 mi | 9h 42m | Iberia, Air Europa, and American Airlines | 3-4/day |
| 19 | MIA to CMN Casablanca, Morocco | 4,313 mi | 9h 29m | Royal Air Maroc | 3×/wk |
| 20 | MIA to GIG Rio de Janeiro, Brazil | 4,174 mi | 9h 12m | American Airlines | 1/day |
| 21 | MIA to LIS Lisbon, Portugal | 4,149 mi | 9h 9m | TAP Air Portugal | 1-2/day |
| 22 | MIA to SCL Santiago, Chile | 4,137 mi | 9h 7m | LATAM and American Airlines | 2-3/day |
| 23 | MIA to COR Cordoba, Argentina | 4,087 mi | 9h 1m | American Airlines | weekly |
| 24 | MIA to GRU Sao Paulo, Brazil | 4,085 mi | 9h 1m | LATAM Airlines and American Airlines | 3-4/day |
| 25 | MIA to VCP Campinas, Brazil | 4,036 mi | 8h 55m | Korean Air | 2×/wk |