| 1 | MNL to JFK New York, United States | 8,510 mi | 18h 9m | Philippine Airlines | 2×/wk |
| 2 | MNL to EWR Newark, United States | 8,500 mi | 18h 7m | Philippine Airlines | weekly |
| 3 | MNL to YYZ Toronto, Canada | 8,210 mi | 17h 31m | Philippine Airlines | 3×/wk |
| 4 | MNL to LAX Los Angeles, United States | 7,295 mi | 15h 38m | Philippine Airlines | 2-3/day |
| 5 | MNL to SFO San Francisco, United States | 6,977 mi | 14h 59m | United Airlines and Philippine Airlines | 3-4/day |
| 6 | MNL to SEA Seattle, United States | 6,652 mi | 14h 18m | Philippine Airlines | 1/day |
| 7 | MNL to YVR Vancouver, Canada | 6,558 mi | 14h 7m | Philippine Airlines and Air Canada | 1-2/day |
| 8 | MNL to IST Istanbul, Türkiye | 5,676 mi | 12h 18m | Turkish Airlines | 1/day |
| 9 | MNL to JED Jeddah, Saudi Arabia | 5,341 mi | 11h 36m | Saudia | 1/day |
| 10 | MNL to HNL Honolulu, United States | 5,295 mi | 11h 30m | Philippine Airlines | 1/day |
| 11 | MNL to RUH Riyadh, Saudi Arabia | 4,833 mi | 10h 33m | Philippine Airlines, Saudia, and Cebu Pacific Air | 2-3/day |
| 12 | MNL to KWI Kuwait City, Kuwait | 4,723 mi | 10h 20m | Kuwait | 1/day |
| 13 | MNL to BAH Manama, Bahrain | 4,579 mi | 10h 2m | Gulf Air | 1/day |
| 14 | MNL to DOH Doha, Qatar | 4,525 mi | 9h 55m | Qatar Airways | 2-3/day |
| 15 | MNL to AUH Abu Dhabi, United Arab Emirates | 4,340 mi | 9h 32m | Etihad Airways | 1-2/day |
| 16 | MNL to DXB Dubai, United Arab Emirates | 4,291 mi | 9h 26m | Emirates | 3-4/day |
| 17 | MNL to MCT Muscat, Oman | 4,115 mi | 9h 4m | Oman Air | 1/day |
| 18 | MNL to MEL Melbourne, Australia | 3,923 mi | 8h 41m | Cebu Pacific Air and Philippine Airlines | 6×/wk |
| 19 | MNL to SYD Sydney, Australia | 3,892 mi | 8h 37m | Qantas, Cebu Pacific Air, and Philippine Airlines | 1-2/day |
| 20 | MNL to BNE Brisbane, Australia | 3,606 mi | 8h 1m | Philippine Airlines and Qantas | 1-2/day |
| 21 | MNL to PER Perth, Australia | 3,227 mi | 7h 14m | Jetstar and Philippine Airlines | 5×/wk |
| 22 | MNL to DEL New Delhi, India | 2,966 mi | 6h 42m | Air India | 1/day |
| 23 | MNL to POM Port Moresby, Papua New Guinea | 2,442 mi | 5h 37m | Air Niugini and Philippine Airlines | 1/day |
| 24 | MNL to NRT Tokyo, Japan | 1,896 mi | 4h 30m | Cebu Pacific Air, Philippine Airlines, and All Nippon Airways | 5-6/day |
| 25 | MNL to HND Tokyo, Japan | 1,862 mi | 4h 25m | Philippine Airlines, All Nippon Airways, and Japan Airlines | 3-4/day |