| 1 | NAP to ATL Atlanta, United States | 5,148 mi | 11h 12m | Delta Air Lines | 1-2/day |
| 2 | NAP to ORD Chicago, United States | 4,933 mi | 10h 46m | American Airlines | 1-2/day |
| 3 | NAP to PIT Pittsburgh, United States | 4,677 mi | 10h 14m | American Airlines | weekly |
| 4 | NAP to PHL Philadelphia, United States | 4,483 mi | 9h 50m | American Airlines | 1/day |
| 5 | NAP to EWR Newark, United States | 4,405 mi | 9h 40m | United Airlines | 1-2/day |
| 6 | NAP to JFK New York, United States | 4,390 mi | 9h 38m | Delta Air Lines | 1/day |
| 7 | NAP to YUL Montreal, Canada | 4,215 mi | 9h 17m | Air Canada | 1/day |
| 8 | NAP to DXB Dubai, United Arab Emirates | 2,582 mi | 5h 55m | flydubai | 1/day |
| 9 | NAP to TFS Tenerife Island, Spain | 1,955 mi | 4h 37m | Ryanair | 2×/wk |
| 10 | NAP to FUE Fuerteventura Island, Spain | 1,804 mi | 4h 18m | easyJet | weekly |
| 11 | NAP to EVN Yerevan, Armenia | 1,574 mi | 3h 50m | Wizz Air Malta | 2×/wk |
| 12 | NAP to RMF Marsa Alam, Egypt | 1,573 mi | 3h 50m | easyJet | weekly |
| 13 | NAP to SSH Sharm el-Sheikh, Egypt | 1,446 mi | 3h 34m | easyJet, Air Cairo, and Wizz Air Malta | 1-2/day |
| 14 | NAP to HEL Helsinki, Finland | 1,418 mi | 3h 30m | Finnair | 1/day |
| 15 | NAP to RAK Marrakech, Morocco | 1,394 mi | 3h 28m | easyJet and Ryanair | 4×/wk |
| 16 | NAP to SNN Shannon, Ireland | 1,358 mi | 3h 23m | Ryanair | 2×/wk |
| 17 | NAP to OSL Oslo, Norway | 1,341 mi | 3h 21m | Norwegian Air Shuttle | 2×/wk |
| 18 | NAP to GLA Glasgow, United Kingdom | 1,337 mi | 3h 20m | Jet2 and TUI | weekly |
| 19 | NAP to EDI Edinburgh, United Kingdom | 1,311 mi | 3h 17m | easyJet, Jet2, and Ryanair | 7×/wk |
| 20 | NAP to CMN Casablanca, Morocco | 1,308 mi | 3h 17m | Air Arabia Maroc and Royal Air Maroc | 5×/wk |
| 21 | NAP to ARN Stockholm, Sweden | 1,306 mi | 3h 17m | Scandinavian Airlines | 2×/wk |
| 22 | NAP to TLV Tel Aviv, Israel | 1,294 mi | 3h 15m | El Al, Israir, and Wizz Air Malta | 8×/wk |
| 23 | NAP to DUB Dublin, Ireland | 1,289 mi | 3h 15m | Aer Lingus and Ryanair | 2/day |
| 24 | NAP to LIS Lisbon, Portugal | 1,248 mi | 3h 9m | TAP Air Portugal and Ryanair | 1-2/day |
| 25 | NAP to NCL Newcastle, United Kingdom | 1,220 mi | 3h 6m | TUI | 2×/wk |