| 1 | OKC to SEA Seattle, United States | 1,517 mi | 3h 43m | Alaska Airlines | 1-2/day |
| 2 | OKC to LGA New York, United States | 1,338 mi | 3h 21m | American Airlines and Delta Air Lines | 2-3/day |
| 3 | OKC to MIA Miami, United States | 1,222 mi | 3h 6m | American Airlines | 1-2/day |
| 4 | OKC to LAX Los Angeles, United States | 1,184 mi | 3h 2m | United Airlines and American Airlines | 2-3/day |
| 5 | OKC to BWI Baltimore, United States | 1,177 mi | 3h 1m | Southwest Airlines | weekly |
| 6 | OKC to DCA Washington, United States | 1,155 mi | 2h 58m | Southwest Airlines and American Airlines | 2-3/day |
| 7 | OKC to BOI Boise, United States | 1,139 mi | 2h 56m | United Airlines | weekly |
| 8 | OKC to IAD Washington, United States | 1,133 mi | 2h 55m | United Airlines | weekly |
| 9 | OKC to MCO Orlando, United States | 1,068 mi | 2h 47m | Southwest Airlines | 1-2/day |
| 10 | OKC to SFB Orlando, United States | 1,060 mi | 2h 46m | Allegiant Air | 2×/wk |
| 11 | OKC to LAS Las Vegas, United States | 984 mi | 2h 37m | Southwest Airlines, Frontier Airlines, and Allegiant Air | 3-4/day |
| 12 | OKC to CLT Charlotte, United States | 938 mi | 2h 31m | American Airlines | 2-3/day |
| 13 | OKC to SLC Salt Lake City, United States | 865 mi | 2h 22m | Delta Air Lines | 2/day |
| 14 | OKC to PHX Phoenix, United States | 832 mi | 2h 18m | United Airlines, Southwest Airlines, and American Airlines | 5-6/day |
| 15 | OKC to ATL Atlanta, United States | 759 mi | 2h 9m | Delta Air Lines and Frontier Airlines | 5-6/day |
| 16 | OKC to SBN South Bend, United States | 749 mi | 2h 8m | United Airlines | weekly |
| 17 | OKC to MKE Milwaukee, United States | 736 mi | 2h 6m | United Airlines | weekly |
| 18 | OKC to VPS Valparaiso/Destin-Ft Walton Beach, United States | 726 mi | 2h 5m | Allegiant Air | 1/day |
| 19 | OKC to CEW Crestview, United States | 716 mi | 2h 4m | FFP | weekly |
| 20 | OKC to MSP Minneapolis, United States | 695 mi | 2h 1m | Delta Air Lines | 2/day |
| 21 | OKC to ORD Chicago, United States | 692 mi | 2h 1m | United Airlines and American Airlines | 8-9/day |
| 22 | OKC to MDW Chicago, United States | 691 mi | 2h | Southwest Airlines | 2-3/day |
| 23 | OKC to GUF Gulf Shores, United States | 675 mi | 1h 59m | Allegiant Air | 3×/wk |
| 24 | OKC to RAP Rapid City, United States | 664 mi | 1h 57m | United Airlines | weekly |
| 25 | OKC to BNA Nashville, United States | 614 mi | 1h 51m | Southwest Airlines | 2-3/day |