| 1 | PHX to TPE Taipei, Taiwan | 7,092 mi | 15h 13m | Starlux Airlines and China | 7×/wk |
| 2 | PHX to MAD Madrid, Spain | 5,594 mi | 12h 8m | OMD | weekly |
| 3 | PHX to CDG Paris, France | 5,468 mi | 11h 52m | Air France | 1/day |
| 4 | PHX to LHR London, United Kingdom | 5,259 mi | 11h 26m | British Airways and American Airlines | 1-2/day |
| 5 | PHX to HNL Honolulu, United States | 2,913 mi | 6h 36m | American Airlines, Alaska Airlines, and Southwest Airlines | 3-4/day |
| 6 | PHX to KOA Kailua-Kona, United States | 2,856 mi | 6h 29m | American Airlines | 1/day |
| 7 | PHX to OGG Kahului, United States | 2,841 mi | 6h 27m | American Airlines and Southwest Airlines | 3/day |
| 8 | PHX to ANC Anchorage, United States | 2,549 mi | 5h 51m | Alaska Airlines and American Airlines | 1-2/day |
| 9 | PHX to BOS Boston, United States | 2,295 mi | 5h 19m | American Airlines and Delta Air Lines | 5-6/day |
| 10 | PHX to YUL Montreal, Canada | 2,179 mi | 5h 5m | Air Canada | 1/day |
| 11 | PHX to JFK New York, United States | 2,149 mi | 5h 1m | American Airlines, Delta Air Lines, and JetBlue Airways | 8-9/day |
| 12 | PHX to EWR Newark, United States | 2,128 mi | 4h 58m | United Airlines, American Airlines, and TCA | 7/day |
| 13 | PHX to MMU Morristown, United States | 2,116 mi | 4h 57m | JRE | weekly |
| 14 | PHX to PHL Philadelphia, United States | 2,071 mi | 4h 51m | American Airlines and Delta Air Lines | 7-8/day |
| 15 | PHX to BWI Baltimore, United States | 1,994 mi | 4h 42m | Southwest Airlines and American Airlines | 3/day |
| 16 | PHX to DCA Washington, United States | 1,975 mi | 4h 39m | American Airlines | 2-3/day |
| 17 | PHX to MIA Miami, United States | 1,969 mi | 4h 39m | American Airlines | 5/day |
| 18 | PHX to FLL Fort Lauderdale, United States | 1,969 mi | 4h 39m | American Airlines | 1/day |
| 19 | PHX to IAD Washington, United States | 1,952 mi | 4h 37m | United Airlines and American Airlines | 1-2/day |
| 20 | PHX to BUF Buffalo, United States | 1,908 mi | 4h 31m | Southwest Airlines | weekly |
| 21 | PHX to RDU Raleigh, United States | 1,887 mi | 4h 29m | American Airlines and Southwest Airlines | 2-3/day |
| 22 | PHX to YYZ Toronto, Canada | 1,872 mi | 4h 27m | Porter and Air Canada | 1-2/day |
| 23 | PHX to MCO Orlando, United States | 1,845 mi | 4h 23m | American Airlines, Southwest Airlines, and Frontier Airlines | 5/day |
| 24 | PHX to PIT Pittsburgh, United States | 1,810 mi | 4h 19m | American Airlines and Southwest Airlines | 2-3/day |
| 25 | PHX to TPA Tampa, United States | 1,785 mi | 4h 16m | American Airlines and Southwest Airlines | 3/day |