| 1 | PTY to IST Istanbul, Türkiye | 6,723 mi | 14h 27m | Turkish Airlines | 1-2/day |
| 2 | PTY to AMS Amsterdam, Netherlands | 5,476 mi | 11h 53m | KLM | 1/day |
| 3 | PTY to CDG Paris, France | 5,381 mi | 11h 41m | Air France | 1/day |
| 4 | PTY to MAD Madrid, Spain | 5,069 mi | 11h 2m | Air Europa and Iberia | 1-2/day |
| 5 | PTY to MVD Montevideo, Uruguay | 3,396 mi | 7h 35m | Copa | 2-3/day |
| 6 | PTY to EZE Buenos Aires, Argentina | 3,325 mi | 7h 27m | Copa | 5-6/day |
| 7 | PTY to SFO San Francisco, United States | 3,321 mi | 7h 26m | Copa | 1-2/day |
| 8 | PTY to GIG Rio de Janeiro, Brazil | 3,290 mi | 7h 22m | Copa | 2-3/day |
| 9 | PTY to POA Porto Alegre, Brazil | 3,286 mi | 7h 22m | Copa | 1/day |
| 10 | PTY to FLN Florianopolis, Brazil | 3,270 mi | 7h 20m | Copa | 1/day |
| 11 | PTY to SSA Salvador, Brazil | 3,201 mi | 7h 11m | Copa | 1/day |
| 12 | PTY to GRU Sao Paulo, Brazil | 3,160 mi | 7h 6m | Copa | 5-6/day |
| 13 | PTY to ROS Rosario, Argentina | 3,148 mi | 7h 5m | Copa | 1/day |
| 14 | PTY to CNF Belo Horizonte, Brazil | 3,120 mi | 7h 1m | Copa | 1-2/day |
| 15 | PTY to LAX Los Angeles, United States | 3,011 mi | 6h 48m | Copa | 3-4/day |
| 16 | PTY to SCL Santiago, Chile | 2,988 mi | 6h 45m | Copa | 4-5/day |
| 17 | PTY to MDZ Mendoza, Argentina | 2,978 mi | 6h 44m | Copa | 1/day |
| 18 | PTY to COR Cordoba, Argentina | 2,966 mi | 6h 42m | Copa | 3/day |
| 19 | PTY to LAS Las Vegas, United States | 2,918 mi | 6h 36m | Copa | 1/day |
| 20 | PTY to SAN San Diego, United States | 2,911 mi | 6h 35m | Copa | 1/day |
| 21 | PTY to ASU Asuncion, Paraguay | 2,790 mi | 6h 20m | Copa | 2-3/day |
| 22 | PTY to BSB Brasilia, Brazil | 2,757 mi | 6h 16m | Copa | 1/day |
| 23 | PTY to TUC San Miguel de Tucuman, Argentina | 2,660 mi | 6h 4m | Copa | 1/day |
| 24 | PTY to DEN Denver, United States | 2,636 mi | 6h 1m | Copa | 1/day |
| 25 | PTY to YUL Montreal, Canada | 2,537 mi | 5h 49m | Copa | 1/day |