| Panama City (PTY) Tocumen International Airport | Panama | 988 mi | 2h 37m | Copa | 8/day |
| Miami (MIA) Miami International Airport | United States | 911 mi | 2h 28m | American Airlines, Sky High Aviation, and Frontier Airlines | 6-7/day |
| New York (JFK) John F Kennedy International Airport | United States | 1,559 mi | 3h 48m | JetBlue Airways, American Airlines, and Delta Air Lines | 6/day |
| San Juan (SJU) Luis Munoz Marin International Airport | United States | 155 mi | 54m | JetBlue Airways, Frontier Airlines, and Arajet | 5-6/day |
| Atlanta (ATL) Hartsfield/Jackson Atlanta International Airport | United States | 1,438 mi | 3h 33m | Delta Air Lines and Frontier Airlines | 4-5/day |
| Charlotte (CLT) Charlotte/Douglas International Airport | United States | 1,384 mi | 3h 26m | American Airlines | 3-4/day |
| Newark (EWR) Newark Liberty International Airport | United States | 1,567 mi | 3h 49m | United Airlines, JetBlue Airways, and Arajet | 3-4/day |
| Orlando (MCO) Orlando International Airport | United States | 1,065 mi | 2h 47m | JetBlue Airways and Southwest Airlines | 3-4/day |
| Philadelphia (PHL) Philadelphia International Airport | United States | 1,528 mi | 3h 44m | American Airlines and Frontier Airlines | 3/day |
| Toronto (YYZ) Toronto Pearson International Airport | Canada | 1,854 mi | 4h 25m | Air Canada, Air Transat, and WestJet | 2-3/day |
| Chicago (ORD) Chicago O'Hare International Airport | United States | 1,983 mi | 4h 41m | American Airlines, United Airlines, and Arajet | 2-3/day |
| Montreal (YUL) Montréal-Pierre Elliott Trudeau International Airport | Canada | 1,884 mi | 4h 28m | Air Transat, Air Canada, and Arajet | 2-3/day |
| Baltimore (BWI) Baltimore/Washington International Thurgood Marshall Airport | United States | 1,508 mi | 3h 42m | Southwest Airlines | 2-3/day |
| Dallas (DFW) Dallas-Fort Worth International Airport | United States | 2,031 mi | 4h 46m | American Airlines and Sun Country Airlines | 2/day |
| Boston (BOS) General Edward Lawrence Logan International Airport | United States | 1,651 mi | 3h 59m | JetBlue Airways | 1-2/day |
| Fort Lauderdale (FLL) Fort Lauderdale/Hollywood International Airport | United States | 914 mi | 2h 28m | JetBlue Airways | 1-2/day |
| Cancun (CUN) Cancun International Airport | Mexico | 1,215 mi | 3h 5m | Arajet and Aerolineas Argentinas | 1-2/day |
| Houston (IAH) George Bush Intcntl/Houston Airport | United States | 1,867 mi | 4h 26m | United Airlines | 1-2/day |
| Washington (IAD) Washington Dulles International Airport | United States | 1,510 mi | 3h 42m | United Airlines | 1-2/day |
| Denver (DEN) Denver International Airport | United States | 2,610 mi | 5h 58m | United Airlines | 1/day |
| Mexico City (MEX) Licenciado Benito Juarez International Airport | Mexico | 2,004 mi | 4h 43m | Aeromexico | 1/day |
| Reyes Acozac (NLU) Santa Lucia Air Force Base | Mexico | 2,000 mi | 4h 43m | Arajet | 1/day |
| Nashville (BNA) Nashville International Airport | United States | 1,648 mi | 3h 59m | Southwest Airlines | 1/day |
| Chicago (MDW) Chicago Midway International Airport | United States | 1,968 mi | 4h 39m | Southwest Airlines | 1/day |
| Minneapolis (MSP) Minneapolis-St Paul International/Wold-Chamberlain Airport | United States | 2,313 mi | 5h 21m | Delta Air Lines | 1/day |
| St. Louis (STL) St Louis Lambert International Airport | United States | 1,919 mi | 4h 33m | Frontier Airlines and Southwest Airlines | 1/day |
| Tampa (TPA) Tampa International Airport | United States | 1,108 mi | 2h 52m | JetBlue Airways and Frontier Airlines | 4×/wk |
| Kingston (KIN) Norman Manley International Airport | Jamaica | 554 mi | 1h 44m | Arajet | 1/day |
| Orlando (SFB) Orlando Sanford International Airport | United States | 1,076 mi | 2h 48m | Arajet | 3×/wk |
| Houston (HOU) William P Hobby Airport | United States | 1,856 mi | 4h 25m | Southwest Airlines | 2×/wk |
| Detroit (DTW) Detroit Metro Wayne County Airport | United States | 1,855 mi | 4h 25m | Delta Air Lines and Frontier Airlines | weekly |
| Cleveland (CLE) Cleveland-Hopkins International Airport | United States | 1,768 mi | 4h 14m | Frontier Airlines | 2×/wk |
| Raleigh (RDU) Raleigh-Durham International Airport | United States | 1,355 mi | 3h 23m | Breeze | 2×/wk |
| Havana (HAV) Jose Marti International Airport | Cuba | 957 mi | 2h 33m | Sky High Aviation | 2×/wk |
| Willemstad (CUR) Hato International Airport | Curaçao | 442 mi | 1h 30m | TUI Nederland (Netherlands) | 2×/wk |
| Kansas City (MCI) Kansas City International Airport | United States | 2,127 mi | 4h 58m | Southwest Airlines | weekly |
| Quebec City (YQB) Québec City Jean Lesage International Airport | Canada | 1,958 mi | 4h 37m | Air Transat | weekly |