| 1 | QRO to MAD Madrid, Spain | 5,636 mi | ~12h 13m | Evelop | weekly |
| 2 | QRO to DTW Detroit, United States | 1,785 mi | ~4h 16m | Aeromexico | 1/day |
| 3 | QRO to ORD Chicago, United States | 1,640 mi | ~3h 58m | Volaris | 2×/wk |
| 4 | QRO to LAX Los Angeles, United States | 1,445 mi | ~3h 34m | Volaris | 2×/wk |
| 5 | QRO to DEN Denver, United States | 1,356 mi | ~3h 23m | Volaris | 2×/wk |
| 6 | QRO to TIJ Tijuana, Mexico | 1,321 mi | ~3h 19m | Volaris | 1/day |
| 7 | QRO to ATL Atlanta, United States | 1,319 mi | ~3h 18m | Aeromexico and Delta Air Lines | 1-2/day |
| 8 | QRO to MCO Orlando, United States | 1,301 mi | ~3h 16m | Volaris | 2×/wk |
| 9 | QRO to DFW Dallas, United States | 870 mi | ~2h 23m | American Airlines, Volaris, and VivaAerobus | 3-4/day |
| 10 | QRO to CUN Cancun, Mexico | 860 mi | ~2h 21m | Volaris and VivaAerobus | 2-3/day |
| 11 | QRO to IAH Houston, United States | 714 mi | ~2h 3m | United Airlines, Volaris, and VivaAerobus | 3-4/day |
| 12 | QRO to MID Merida, Mexico | 680 mi | ~1h 59m | VivaAerobus | 1/day |
| 13 | QRO to SJD San Jose del Cabo, Mexico | 636 mi | ~1h 54m | VivaAerobus | 3×/wk |
| 14 | QRO to SAT San Antonio, United States | 625 mi | ~1h 52m | Volaris and VivaAerobus | 5×/wk |
| 15 | QRO to LRD Laredo, United States | 481 mi | ~1h 35m | Aeronaves TSM | 3×/wk |
| 16 | QRO to MZT Mazatlan, Mexico | 428 mi | ~1h 28m | Volaris | 1/day |
| 17 | QRO to DGO Durango, Mexico | 368 mi | ~1h 21m | Volaris | 3×/wk |
| 18 | QRO to MTY Monterrey, Mexico | 357 mi | ~1h 19m | VivaAerobus and Volaris | 5-6/day |
| 19 | QRO to OAX Oaxaca, Mexico | 337 mi | ~1h 17m | Volaris | 3×/wk |
| 20 | QRO to PVR Puerto Vallarta, Mexico | 328 mi | ~1h 16m | Volaris | 1/day |
| 21 | QRO to VER Veracruz, Mexico | 279 mi | ~1h 10m | Volaris | 3×/wk |
| 22 | QRO to ACA Acapulco, Mexico | 268 mi | ~1h 8m | Volaris | 3×/wk |
| 23 | QRO to ZIH Ixtapa, Mexico | 224 mi | ~1h 3m | Volaris | 3×/wk |
| 24 | QRO to GDL Guadalajara, Mexico | 202 mi | ~1h | Volaris | 1/day |
| 25 | QRO to MEX Mexico City, Mexico | 109 mi | ~48m | Aeromexico | 2-3/day |