| Panama City (PTY) Tocumen International Airport | Panama | 335 mi | 1h 16m | Copa and Avianca | 10/day |
| Houston (IAH) George Bush Intcntl/Houston Airport | United States | 1,556 mi | 3h 48m | United Airlines | 4-5/day |
| Santa Clara (SAL) El Salvador International Airport | El Salvador | 405 mi | 1h 25m | Avianca | 4/day |
| Orlando (MCO) Orlando International Airport | United States | 1,288 mi | 3h 14m | Southwest Airlines, Volaris Costa Rica, and JetBlue Airways | 3-4/day |
| Mexico City (MEX) Licenciado Benito Juarez International Airport | Mexico | 1,187 mi | 3h 2m | Aeromexico and Avianca | 3/day |
| Guatemala City (GUA) La Aurora Airport | Guatemala | 531 mi | 1h 41m | Avianca and Copa | 3/day |
| Quepos (XQP) Quepos Managua Airport | Costa Rica | 38 mi | 40m | GetJet | 3/day |
| Miami (MIA) Miami International Airport | United States | 1,122 mi | 2h 54m | American Airlines | 2-3/day |
| Nicoya (NOB) Nosara Airport | Costa Rica | 98 mi | 47m | GetJet | 2-3/day |
| Puerto Jimenez (PJM) Puerto Jimenez Airport | Costa Rica | 118 mi | 50m | GetJet | 1-2/day |
| Los Angeles (LAX) Los Angeles International Airport | United States | 2,723 mi | 6h 12m | Alaska Airlines and United Airlines | 1-2/day |
| Atlanta (ATL) Hartsfield/Jackson Atlanta International Airport | United States | 1,634 mi | 3h 57m | Delta Air Lines | 1-2/day |
| Houston (HOU) William P Hobby Airport | United States | 1,534 mi | 3h 45m | Southwest Airlines | 1-2/day |
| San Francisco (SFO) San Francisco International Airport | United States | 3,041 mi | 6h 51m | United Airlines | 1/day |
| Newark (EWR) Newark Liberty International Airport | United States | 2,208 mi | 5h 8m | United Airlines | 1/day |
| Dallas (DFW) Dallas-Fort Worth International Airport | United States | 1,781 mi | 4h 15m | American Airlines | 1/day |
| Fort Lauderdale (FLL) Fort Lauderdale/Hollywood International Airport | United States | 1,142 mi | 2h 56m | JetBlue Airways | 1/day |
| Cancun (CUN) Cancun International Airport | Mexico | 783 mi | 2h 12m | Volaris Costa Rica and Volaris | 1/day |
| New York (JFK) John F Kennedy International Airport | United States | 2,211 mi | 5h 9m | JetBlue Airways | 1/day |
| Charlotte (CLT) Charlotte/Douglas International Airport | United States | 1,755 mi | 4h 12m | American Airlines | 1/day |
| Toronto (YYZ) Toronto Pearson International Airport | Canada | 2,343 mi | 5h 25m | Air Canada | 1/day |
| Montreal (YUL) Montréal-Pierre Elliott Trudeau International Airport | Canada | 2,529 mi | 5h 48m | Air Canada and Air Transat | 3×/wk |
| Denver (DEN) Denver International Airport | United States | 2,416 mi | 5h 34m | United Airlines and Southwest Airlines | 3×/wk |
| Managua (MGA) Augusto C. Sandino (Managua) International Airport | Nicaragua | 199 mi | 1h | Copa | 3×/wk |
| Baltimore (BWI) Baltimore/Washington International Thurgood Marshall Airport | United States | 2,069 mi | 4h 51m | Southwest Airlines | 2×/wk |
| Monterrey (MTY) General Mariano Escobedo International Airport | Mexico | 1,507 mi | 3h 42m | VivaAerobus | 2×/wk |
| Guadalajara (GDL) Don Miguel Hidalgo Y Costilla International Airport | Mexico | 1,464 mi | 3h 36m | Volaris Costa Rica | 2×/wk |
| Santo Domingo (SDQ) Las Americas International Airport | Dominican Republic | 1,134 mi | 2h 55m | Arajet | 2×/wk |
| Chicago (ORD) Chicago O'Hare International Airport | United States | 2,221 mi | 5h 10m | United Airlines | weekly |
| Liberia (LIR) Daniel Oduber Quiros International Airport | Costa Rica | 100 mi | 47m | Edelweiss Air | weekly |