| 1 | SNA to JFK New York, United States | 2,449 mi | 5h 38m | Delta Air Lines and American Airlines | 1-2/day |
| 2 | SNA to EWR Newark, United States | 2,428 mi | 5h 36m | United Airlines | 2-3/day |
| 3 | SNA to RDU Raleigh, United States | 2,208 mi | 5h 8m | Breeze | 2×/wk |
| 4 | SNA to MCO Orlando, United States | 2,183 mi | 5h 5m | Breeze | 3×/wk |
| 5 | SNA to PIT Pittsburgh, United States | 2,110 mi | 4h 56m | American Airlines and Southwest Airlines | weekly |
| 6 | SNA to CLT Charlotte, United States | 2,094 mi | 4h 54m | American Airlines | 1/day |
| 7 | SNA to CMH Columbus, United States | 1,969 mi | 4h 39m | Breeze | 2×/wk |
| 8 | SNA to DTW Detroit, United States | 1,956 mi | 4h 37m | Delta Air Lines | 1/day |
| 9 | SNA to ATL Atlanta, United States | 1,915 mi | 4h 32m | Delta Air Lines | 3/day |
| 10 | SNA to CVG Cincinnati, United States | 1,873 mi | 4h 27m | Allegiant Air | 2×/wk |
| 11 | SNA to GRR Grand Rapids, United States | 1,852 mi | 4h 24m | Allegiant Air and United Airlines | 3×/wk |
| 12 | SNA to IND Indianapolis, United States | 1,788 mi | 4h 16m | American Airlines | weekly |
| 13 | SNA to MKE Milwaukee, United States | 1,735 mi | 4h 10m | American Airlines | weekly |
| 14 | SNA to ATW Appleton, United States | 1,726 mi | 4h 9m | Allegiant Air | 2×/wk |
| 15 | SNA to ORD Chicago, United States | 1,722 mi | 4h 8m | American Airlines and United Airlines | 5-6/day |
| 16 | SNA to MSP Minneapolis, United States | 1,520 mi | 3h 43m | Delta Air Lines | 1-2/day |
| 17 | SNA to DSM Des Moines, United States | 1,426 mi | 3h 32m | Allegiant Air | 2×/wk |
| 18 | SNA to IAH Houston, United States | 1,344 mi | 3h 21m | United Airlines | 3/day |
| 19 | SNA to TUL Tulsa, United States | 1,254 mi | 3h 10m | American Airlines | weekly |
| 20 | SNA to XWA Williston, United States | 1,244 mi | 3h 9m | RGY | weekly |
| 21 | SNA to YYC Calgary, Canada | 1,220 mi | 3h 6m | WestJet | 2×/wk |
| 22 | SNA to DAL Dallas, United States | 1,214 mi | 3h 5m | Southwest Airlines | 1-2/day |
| 23 | SNA to AUS Austin, United States | 1,206 mi | 3h 4m | Southwest Airlines | 1/day |
| 24 | SNA to DFW Dallas, United States | 1,202 mi | 3h 4m | American Airlines and Frontier Airlines | 8-9/day |
| 25 | SNA to SAT San Antonio, United States | 1,175 mi | 3h | RGY | weekly |