| 1 | STS to DFW Dallas, United States | 1,492 mi | 3h 40m | American Airlines | 1-2/day |
| 2 | STS to DEN Denver, United States | 974 mi | 2h 36m | Southwest Airlines | weekly |
| 3 | STS to MTJ Montrose, United States | 806 mi | 2h 15m | WCC | weekly |
| 4 | STS to PHX Phoenix, United States | 698 mi | 2h 1m | United Airlines and American Airlines | 3-4/day |
| 5 | STS to SEA Seattle, United States | 618 mi | 1h 52m | Alaska Airlines and American Airlines | 1-2/day |
| 6 | STS to SAN San Diego, United States | 509 mi | 1h 38m | Alaska Airlines, Southwest Airlines, and American Airlines | 4-5/day |
| 7 | STS to PDX Portland, United States | 489 mi | 1h 36m | Alaska Airlines and American Airlines | 2-3/day |
| 8 | STS to LAS Las Vegas, United States | 453 mi | 1h 31m | Alaska Airlines and Southwest Airlines | 2/day |
| 9 | STS to SNA Santa Ana, United States | 433 mi | 1h 29m | American Airlines, Alaska Airlines, and WCC | 3-4/day |
| 10 | STS to ONT Ontario, United States | 423 mi | 1h 27m | Alaska Airlines and American Airlines | 1/day |
| 11 | STS to LAX Los Angeles, United States | 400 mi | 1h 24m | American Airlines, Alaska Airlines, and Advanced Air | 3/day |
| 12 | STS to BUR Burbank, United States | 387 mi | 1h 23m | American Airlines, Southwest Airlines, and Alaska Airlines | 3/day |
| 13 | STS to VNY Van Nuys, United States | 382 mi | 1h 22m | Air Tahiti Nui and WCC | weekly |
| 14 | STS to RDD Redding, United States | 141 mi | 52m | REACH Air Medical Services | 2×/wk |
| 15 | STS to MCC Sacramento, United States | 77 mi | 45m | Calstar | weekly |
| 16 | STS to SQL San Carlos, United States | 75 mi | 44m | BYF | weekly |
| 17 | STS to OAK Oakland, United States | 63 mi | 43m | Redding Aero Enterprises | 1/day |
| 18 | STS to APC Napa, United States | 35 mi | 39m | REACH Air Medical Services | 2×/wk |