| San Juan (SJU) Luis Munoz Marin International Airport | United States | 68 mi | ~43m | United Airlines, Air Flamenco, and JetBlue Airways | 8-9/day |
| Christiansted (STX) Henry E Rohlsen Airport | United States | 45 mi | ~41m | United Airlines | 7-8/day |
| Atlanta (ATL) Hartsfield/Jackson Atlanta International Airport | United States | 1,600 mi | ~3h 53m | Delta Air Lines | 2-3/day |
| Miami (MIA) Miami International Airport | United States | 1,107 mi | ~2h 52m | American Airlines | 2-3/day |
| New York (JFK) John F Kennedy International Airport | United States | 1,627 mi | ~3h 56m | American Airlines and Delta Air Lines | 2/day |
| Charlotte (CLT) Charlotte/Douglas International Airport | United States | 1,522 mi | ~3h 43m | American Airlines | 2/day |
| Houston (IAH) George Bush Intcntl/Houston Airport | United States | 2,068 mi | ~4h 51m | United Airlines | 1/day |
| Washington (IAD) Washington Dulles International Airport | United States | 1,609 mi | ~3h 54m | United Airlines | 1/day |
| Orlando (MCO) Orlando International Airport | United States | 1,247 mi | ~3h 9m | Southwest Airlines | 1/day |
| Charlestown (NEV) Vance W. Amory International Airport | St. Kitts & Nevis | 175 mi | ~57m | United Airlines | 1/day |
| Dallas (DFW) Dallas-Fort Worth International Airport | United States | 2,224 mi | ~5h 10m | American Airlines | 1/day |
| Basseterre (SKB) Robert L. Bradshaw International Airport | St. Kitts & Nevis | 164 mi | ~55m | United Airlines | 1/day |
| Baltimore (BWI) Baltimore/Washington International Thurgood Marshall Airport | United States | 1,601 mi | ~3h 53m | Southwest Airlines | 3×/wk |
| Marigot (DOM) Melville Hall Airport | Dominica | 310 mi | ~1h 13m | American Airlines | 3×/wk |
| Newark (EWR) Newark Liberty International Airport | United States | 1,638 mi | ~3h 58m | United Airlines | 2×/wk |
| St. George (ANU) V.C. Bird International Airport | Antigua & Barbuda | 225 mi | ~1h 3m | Naysa | 2×/wk |
| Chicago (ORD) Chicago O'Hare International Airport | United States | 2,118 mi | ~4h 57m | United Airlines | weekly |
| Philadelphia (PHL) Philadelphia International Airport | United States | 1,609 mi | ~3h 54m | American Airlines | weekly |
| Norfolk (ORF) Norfolk International Airport | United States | 1,452 mi | ~3h 35m | United Airlines | weekly |
| Santo Domingo (SDQ) Las Americas International Airport | Dominican Republic | 308 mi | ~1h 13m | Sky High Aviation | weekly |