| 1 | TLS to YUL Montreal, Canada | 3,559 mi | ~7h 56m | Air Canada and Air Transat | 1/day |
| 2 | TLS to DSS Dakar, Senegal | 2,277 mi | ~5h 17m | Transavia France | weekly |
| 3 | TLS to PFO Paphos, Cyprus | 1,765 mi | ~4h 13m | Ryanair | weekly |
| 4 | TLS to TFS Tenerife Island, Spain | 1,466 mi | ~3h 37m | Ryanair | 2×/wk |
| 5 | TLS to IST Istanbul, Türkiye | 1,399 mi | ~3h 28m | Turkish Airlines | 1/day |
| 6 | TLS to HER Heraklion, Greece | 1,387 mi | ~3h 27m | Volotea | weekly |
| 7 | TLS to ATH Athens, Greece | 1,240 mi | ~3h 9m | Aegean Airlines | 3×/wk |
| 8 | TLS to OSL Oslo, Norway | 1,214 mi | ~3h 5m | Norwegian Air Shuttle | 2×/wk |
| 9 | TLS to AGA Agadir, Morocco | 1,093 mi | ~2h 50m | Ryanair | 2×/wk |
| 10 | TLS to CFU Kerkyra Island, Greece | 995 mi | ~2h 38m | Ryanair | 2×/wk |
| 11 | TLS to RAK Marrakech, Morocco | 976 mi | ~2h 36m | Ryanair, easyJet, and Royal Air Maroc | 2-3/day |
| 12 | TLS to KRK Krakow, Poland | 974 mi | ~2h 36m | Ryanair | 3×/wk |
| 13 | TLS to BUD Budapest, Hungary | 903 mi | ~2h 27m | Ryanair | 2×/wk |
| 14 | TLS to MLA Valletta, Malta | 878 mi | ~2h 24m | Ryanair | 1/day |
| 15 | TLS to EDI Edinburgh, United Kingdom | 877 mi | ~2h 24m | Ryanair | 3×/wk |
| 16 | TLS to CMN Casablanca, Morocco | 857 mi | ~2h 21m | Royal Air Maroc | 1/day |
| 17 | TLS to DJE Djerba, Tunisia | 842 mi | ~2h 19m | Nouvelair Tunisie | weekly |
| 18 | TLS to BRI Bari, Italy | 803 mi | ~2h 14m | Ryanair | 2×/wk |
| 19 | TLS to RBA Rabat, Morocco | 792 mi | ~2h 13m | Ryanair | 3×/wk |
| 20 | TLS to XFW Hamburg, Germany | 785 mi | ~2h 12m | Airbus Transport International and Volotea | 6×/wk |
| 21 | TLS to DUB Dublin, Ireland | 760 mi | ~2h 9m | Aer Lingus and Ryanair | 6×/wk |
| 22 | TLS to FEZ Fez, Morocco | 752 mi | ~2h 8m | Air Arabia Maroc and Ryanair | 4×/wk |
| 23 | TLS to SPU Split, Croatia | 746 mi | ~2h 7m | Volotea | 2×/wk |
| 24 | TLS to BRE Bremen, Germany | 734 mi | ~2h 6m | Airbus Transport International | weekly |
| 25 | TLS to PMO Palermo, Italy | 718 mi | ~2h 4m | Volotea | 2×/wk |