| 1 | TUS to PVG Shanghai, China | 6,870 mi | ~14h 45m | Delta Air Lines | weekly |
| 2 | TUS to ATL Atlanta, United States | 1,538 mi | ~3h 45m | Delta Air Lines | 2/day |
| 3 | TUS to ORD Chicago, United States | 1,435 mi | ~3h 33m | American Airlines, Delta Air Lines, and United Airlines | 3/day |
| 4 | TUS to YYC Calgary, Canada | 1,322 mi | ~3h 19m | WestJet | weekly |
| 5 | TUS to SEA Seattle, United States | 1,216 mi | ~3h 6m | Alaska Airlines, Delta Air Lines, and American Airlines | 3/day |
| 6 | TUS to PDX Portland, United States | 1,120 mi | ~2h 54m | Alaska Airlines | 1/day |
| 7 | TUS to SGF Springfield, United States | 1,056 mi | ~2h 46m | Sierra Pacific Airlines | weekly |
| 8 | TUS to IAH Houston, United States | 934 mi | ~2h 31m | United Airlines | 2-3/day |
| 9 | TUS to DFW Dallas, United States | 811 mi | ~2h 15m | American Airlines | 5-6/day |
| 10 | TUS to SFO San Francisco, United States | 751 mi | ~2h 8m | United Airlines and Delta Air Lines | 3/day |
| 11 | TUS to DEN Denver, United States | 639 mi | ~1h 54m | Southwest Airlines and United Airlines | 4-5/day |
| 12 | TUS to SLC Salt Lake City, United States | 602 mi | ~1h 50m | Delta Air Lines | 3/day |
| 13 | TUS to LAX Los Angeles, United States | 450 mi | ~1h 31m | Delta Air Lines, United Airlines, and Southwest Airlines | 7-8/day |
| 14 | TUS to NZY San Diego, United States | 368 mi | ~1h 21m | Southwest Airlines | 2×/wk |
| 15 | TUS to SAN San Diego, United States | 367 mi | ~1h 20m | Southwest Airlines | 1-2/day |
| 16 | TUS to LAS Las Vegas, United States | 365 mi | ~1h 20m | Southwest Airlines | 2-3/day |
| 17 | TUS to DVT Phoenix, United States | 127 mi | ~51m | Oxford Aviation Academy | weekly |
| 18 | TUS to PHX Phoenix, United States | 110 mi | ~49m | United Airlines, American Airlines, and Southwest Airlines | 9-10/day |
| 19 | TUS to MSC Mesa, United States | 103 mi | ~48m | Oxford Aviation Academy | 1/day |
| 20 | TUS to AZA Phoenix, United States | 92 mi | ~46m | Oxford Aviation Academy and UND Aerospace | 1-2/day |