| 1 | BOS to HKG Hong Kong, Hong Kong SAR China | 7,957 mi | 17h | Cathay Pacific | 1/day |
| 2 | BOS to ICN Seoul, South Korea | 6,813 mi | 14h 38m | Korean Air | 1/day |
| 3 | BOS to PEK Beijing, China | 6,721 mi | 14h 27m | Hainan | 3×/wk |
| 4 | BOS to NRT Tokyo, Japan | 6,686 mi | 14h 23m | Japan Airlines | 1/day |
| 5 | BOS to AUH Abu Dhabi, United Arab Emirates | 6,668 mi | 14h 21m | Etihad Airways | 1/day |
| 6 | BOS to DXB Dubai, United Arab Emirates | 6,650 mi | 14h 18m | Emirates | 1/day |
| 7 | BOS to TLV Tel Aviv, Israel | 5,479 mi | 11h 53m | El Al | 1/day |
| 8 | BOS to GRU Sao Paulo, Brazil | 4,808 mi | 10h 30m | LATAM Airlines | 1/day |
| 9 | BOS to IST Istanbul, Türkiye | 4,801 mi | 10h 29m | Turkish Airlines | 1/day |
| 10 | BOS to ATH Athens, Greece | 4,744 mi | 10h 22m | Delta Air Lines | 1/day |
| 11 | BOS to FCO Rome, Italy | 4,082 mi | 9h | Delta Air Lines and ITA | 1-2/day |
| 12 | BOS to VIE Vienna, Austria | 4,042 mi | 8h 55m | Austrian Airlines | 3×/wk |
| 13 | BOS to MUC Munich, Germany | 3,841 mi | 8h 30m | Lufthansa | 1/day |
| 14 | BOS to MXP Milan, Italy | 3,799 mi | 8h 25m | JetBlue Airways and Delta Air Lines | 1-2/day |
| 15 | BOS to NCE Nice, France | 3,797 mi | 8h 25m | Delta Air Lines | 3×/wk |
| 16 | BOS to ZRH Zurich, Switzerland | 3,735 mi | 8h 17m | Swiss International | 2-3/day |
| 17 | BOS to CPH Copenhagen, Denmark | 3,660 mi | 8h 8m | Scandinavian Airlines | 1/day |
| 18 | BOS to FRA Frankfurt, Germany | 3,659 mi | 8h 8m | Lufthansa and Condor | 2-3/day |
| 19 | BOS to BCN Barcelona, Spain | 3,640 mi | 8h 6m | Delta Air Lines, JetBlue Airways, and LVL | 2-3/day |
| 20 | BOS to AMS Amsterdam, Netherlands | 3,447 mi | 7h 42m | Delta Air Lines, JetBlue Airways, and KLM | 4/day |
| 21 | BOS to CDG Paris, France | 3,439 mi | 7h 41m | Air France, Delta Air Lines, and JetBlue Airways | 4/day |
| 22 | BOS to MAD Madrid, Spain | 3,401 mi | 7h 36m | Iberia, Delta Air Lines, and JetBlue Airways | 3-4/day |
| 23 | BOS to ANC Anchorage, United States | 3,373 mi | 7h 33m | Alaska Airlines | weekly |
| 24 | BOS to LGW London, United Kingdom | 3,274 mi | 7h 20m | JetBlue Airways | 1/day |
| 25 | BOS to LHR London, United Kingdom | 3,256 mi | 7h 18m | British Airways, Virgin Atlantic, and American Airlines | 8-9/day |