| 1 | CHA to IFP Bullhead City, United States | 1,653 mi | ~4h | Sun Country Airlines | weekly |
| 2 | CHA to APA Denver, United States | 1,122 mi | ~2h 54m | Kabo Air | weekly |
| 3 | CHA to DEN Denver, United States | 1,116 mi | ~2h 53m | Delta Air Lines | weekly |
| 4 | CHA to SAT San Antonio, United States | 862 mi | ~2h 22m | Sun Country Airlines | weekly |
| 5 | CHA to LGA New York, United States | 733 mi | ~2h 6m | Delta Air Lines | 1-2/day |
| 6 | CHA to ACT Waco, United States | 733 mi | ~2h 6m | American Airlines | weekly |
| 7 | CHA to EWR Newark, United States | 717 mi | ~2h 4m | United Airlines | 1/day |
| 8 | CHA to MIA Miami, United States | 702 mi | ~2h 2m | American Airlines | weekly |
| 9 | CHA to DFW Dallas, United States | 694 mi | ~2h 1m | American Airlines | 3-4/day |
| 10 | CHA to FLL Fort Lauderdale, United States | 688 mi | ~2h | Allegiant Air | 2×/wk |
| 11 | CHA to IAH Houston, United States | 686 mi | ~2h | United Airlines | 2/day |
| 12 | CHA to SHV Shreveport, United States | 526 mi | ~1h 40m | Aeronaves TSM | weekly |
| 13 | CHA to DCA Washington, United States | 522 mi | ~1h 40m | American Airlines | 1/day |
| 14 | CHA to PIE St Petersburg-Clearwater, United States | 514 mi | ~1h 39m | Allegiant Air | 3×/wk |
| 15 | CHA to DTW Detroit, United States | 506 mi | ~1h 38m | Delta Air Lines | 1-2/day |
| 16 | CHA to ORD Chicago, United States | 501 mi | ~1h 37m | United Airlines and American Airlines | 5-6/day |
| 17 | CHA to AEX Alexandria, United States | 496 mi | ~1h 36m | GlobalX Airlines | weekly |
| 18 | CHA to SFB Orlando, United States | 491 mi | ~1h 36m | Allegiant Air | 2×/wk |
| 19 | CHA to SGF Springfield, United States | 481 mi | ~1h 35m | United Airlines | weekly |
| 20 | CHA to PIB Hattiesburg-Laurel, United States | 343 mi | ~1h 17m | Alpine Air Express | weekly |
| 21 | CHA to GSO Greensboro, United States | 305 mi | ~1h 13m | United Airlines | weekly |
| 22 | CHA to CLT Charlotte, United States | 241 mi | ~1h 5m | American Airlines | 7/day |
| 23 | CHA to BHM Birmingham, United States | 135 mi | ~52m | United Airlines | weekly |
| 24 | CHA to BNA Nashville, United States | 112 mi | ~49m | Delta Air Lines | weekly |
| 25 | CHA to ATL Atlanta, United States | 106 mi | ~48m | Delta Air Lines | 8-9/day |