| 1 | FRA to EZE Buenos Aires, Argentina | 7,146 mi | 15h 20m | Lufthansa | 1/day |
| 2 | FRA to SIN Singapore, Singapore | 6,388 mi | 13h 46m | Singapore Airlines and Lufthansa | 3/day |
| 3 | FRA to GRU Sao Paulo, Brazil | 6,087 mi | 13h 9m | LATAM, Lufthansa, and LATAM Airlines | 2-3/day |
| 4 | FRA to SGN Ho Chi Minh City, Vietnam | 6,001 mi | 12h 58m | Vietnam | 1/day |
| 5 | FRA to GIG Rio de Janeiro, Brazil | 5,944 mi | 12h 51m | Lufthansa | 1/day |
| 6 | FRA to MEX Mexico City, Mexico | 5,934 mi | 12h 50m | Lufthansa | 1/day |
| 7 | FRA to CPT Cape Town, South Africa | 5,836 mi | 12h 37m | Lufthansa | 3×/wk |
| 8 | FRA to NRT Tokyo, Japan | 5,821 mi | 12h 36m | Japan Airlines | 1/day |
| 9 | FRA to TPE Taipei, Taiwan | 5,820 mi | 12h 36m | China | 1-2/day |
| 10 | FRA to HND Tokyo, Japan | 5,818 mi | 12h 35m | All Nippon Airways and Lufthansa | 3/day |
| 11 | FRA to SJO San Jose, Costa Rica | 5,811 mi | 12h 34m | Lufthansa | 3×/wk |
| 12 | FRA to LAX Los Angeles, United States | 5,792 mi | 12h 32m | Lufthansa and Condor | 3/day |
| 13 | FRA to MRU Mauritius, Mauritius | 5,717 mi | 12h 23m | Condor | 1/day |
| 14 | FRA to HKG Hong Kong, Hong Kong SAR China | 5,689 mi | 12h 19m | Cathay Pacific and Lufthansa | 2/day |
| 15 | FRA to SFO San Francisco, United States | 5,684 mi | 12h 19m | United Airlines, Condor, and Lufthansa | 4-5/day |
| 16 | FRA to SZX Shenzhen, China | 5,667 mi | 12h 17m | Air China | 2×/wk |
| 17 | FRA to BOG Bogota, Colombia | 5,645 mi | 12h 14m | Lufthansa | 1/day |
| 18 | FRA to CAN Guangzhou, China | 5,606 mi | 12h 9m | China Southern | 3×/wk |
| 19 | FRA to BKK Bangkok, Thailand | 5,593 mi | 12h 7m | Thai Airways and Condor | 2-3/day |
| 20 | FRA to LAS Las Vegas, United States | 5,569 mi | 12h 4m | Eurowings Discover and Condor | 1/day |
| 21 | FRA to PVG Shanghai, China | 5,505 mi | 11h 57m | Lufthansa, Air China, and China Eastern | 3-4/day |
| 22 | FRA to HAN Hanoi, Vietnam | 5,415 mi | 11h 45m | Vietnam | 1/day |
| 23 | FRA to JNB Johannesburg, South Africa | 5,399 mi | 11h 43m | Lufthansa and Condor | 1-2/day |
| 24 | FRA to CUN Cancun, Mexico | 5,347 mi | 11h 37m | Condor | 1/day |
| 25 | FRA to ICN Seoul, South Korea | 5,310 mi | 11h 32m | Lufthansa, Air Incheon, and Asiana Airlines | 3-4/day |