| 1 | GSP to LGG Liege, Belgium | 4,310 mi | ~9h 29m | Air Atlanta Icelandic | 3×/wk |
| 2 | GSP to LAX Los Angeles, United States | 2,052 mi | ~4h 49m | Breeze | 2×/wk |
| 3 | GSP to SLW Saltillo, Mexico | 1,287 mi | ~3h 14m | Aeronaves TSM | 2×/wk |
| 4 | GSP to DEN Denver, United States | 1,276 mi | ~3h 13m | United Airlines | 1/day |
| 5 | GSP to RAP Rapid City, United States | 1,273 mi | ~3h 13m | United Airlines | weekly |
| 6 | GSP to LRD Laredo, United States | 1,136 mi | ~2h 56m | USA Jet Airlines | weekly |
| 7 | GSP to AUS Austin, United States | 955 mi | ~2h 33m | American Airlines | weekly |
| 8 | GSP to DFW Dallas, United States | 860 mi | ~2h 21m | American Airlines | 3-4/day |
| 9 | GSP to IAH Houston, United States | 836 mi | ~2h 19m | United Airlines | 2-3/day |
| 10 | GSP to PVD Providence, United States | 750 mi | ~2h 8m | Breeze | 2×/wk |
| 11 | GSP to BDL Hartford, United States | 709 mi | ~2h 3m | Breeze | 2×/wk |
| 12 | GSP to HVN New Haven, United States | 671 mi | ~1h 58m | Avelo | 2×/wk |
| 13 | GSP to MIA Miami, United States | 639 mi | ~1h 54m | American Airlines | 2-3/day |
| 14 | GSP to FLL Fort Lauderdale, United States | 622 mi | ~1h 52m | Allegiant Air | 1/day |
| 15 | GSP to LGA New York, United States | 610 mi | ~1h 50m | Delta Air Lines and American Airlines | 5-6/day |
| 16 | GSP to EWR Newark, United States | 594 mi | ~1h 49m | United Airlines | 3/day |
| 17 | GSP to ORD Chicago, United States | 578 mi | ~1h 47m | American Airlines and United Airlines | 5-6/day |
| 18 | GSP to RSW Fort Myers, United States | 578 mi | ~1h 47m | Breeze | 3×/wk |
| 19 | GSP to ACY Atlantic City, United States | 525 mi | ~1h 40m | Sun Country Airlines | weekly |
| 20 | GSP to SRQ Sarasota/Bradenton, United States | 519 mi | ~1h 39m | Allegiant Air | 2×/wk |
| 21 | GSP to PHL Philadelphia, United States | 514 mi | ~1h 39m | American Airlines | 3-4/day |
| 22 | GSP to YIP Detroit, United States | 512 mi | ~1h 38m | USA Jet Airlines | 2×/wk |
| 23 | GSP to DTW Detroit, United States | 509 mi | ~1h 38m | Delta Air Lines and United Airlines | 2-3/day |
| 24 | GSP to PIE St Petersburg-Clearwater, United States | 484 mi | ~1h 35m | Allegiant Air | 1/day |
| 25 | GSP to TPA Tampa, United States | 478 mi | ~1h 34m | Breeze | 3×/wk |