| 1 | ISB to YYZ Toronto, Canada | 6,826 mi | ~14h 40m | Pakistan International | weekly |
| 2 | ISB to MAN Manchester, United Kingdom | 3,811 mi | ~8h 27m | Pakistan International | 3×/wk |
| 3 | ISB to LHR London, United Kingdom | 3,761 mi | ~8h 21m | Pakistan International | 3×/wk |
| 4 | ISB to LGW London, United Kingdom | 3,754 mi | ~8h 20m | British Airways | 3×/wk |
| 5 | ISB to CDG Paris, France | 3,663 mi | ~8h 8m | Pakistan International | 2×/wk |
| 6 | ISB to CAN Guangzhou, China | 2,539 mi | ~5h 49m | China Southern | 2×/wk |
| 7 | ISB to IST Istanbul, Türkiye | 2,450 mi | ~5h 38m | Turkish Airlines | 1-2/day |
| 8 | ISB to PEK Beijing, China | 2,437 mi | ~5h 37m | Air China | weekly |
| 9 | ISB to BKK Bangkok, Thailand | 2,225 mi | ~5h 10m | Thai Airways | 1/day |
| 10 | ISB to JED Jeddah, Saudi Arabia | 2,206 mi | ~5h 8m | Saudia, Airblue, and Pakistan International | 1-2/day |
| 11 | ISB to MED Medina, Saudi Arabia | 2,085 mi | ~4h 53m | Airblue and Pakistan International | weekly |
| 12 | ISB to RUH Riyadh, Saudi Arabia | 1,677 mi | ~4h 3m | Airblue, Saudia, and flynas | 3-4/day |
| 13 | ISB to HOF HOF, Saudi Arabia | 1,512 mi | ~3h 42m | Pakistan International | weekly |
| 14 | ISB to KWI Kuwait City, Kuwait | 1,492 mi | ~3h 40m | Kuwait | 3×/wk |
| 15 | ISB to DMM Ad Dammam, Saudi Arabia | 1,458 mi | ~3h 36m | Pakistan International and Airblue | 5×/wk |
| 16 | ISB to BAH Manama, Bahrain | 1,417 mi | ~3h 30m | Gulf Air | 1/day |
| 17 | ISB to DOH Doha, Qatar | 1,396 mi | ~3h 28m | Qatar Airways | 2/day |
| 18 | ISB to GYD Baku, Azerbaijan | 1,340 mi | ~3h 21m | AZAL Azerbaijan | 3×/wk |
| 19 | ISB to AUH Abu Dhabi, United Arab Emirates | 1,263 mi | ~3h 11m | Etihad Airways, Pakistan International, and Airblue | 3-4/day |
| 20 | ISB to AAN Al Ain, United Arab Emirates | 1,221 mi | ~3h 6m | Pakistan International | 2×/wk |
| 21 | ISB to DXB Dubai, United Arab Emirates | 1,195 mi | ~3h 3m | Emirates, flydubai, and Airblue | 6×/wk |
| 22 | ISB to SHJ Sharjah, United Arab Emirates | 1,184 mi | ~3h 2m | Airblue and Pakistan International | 6×/wk |
| 23 | ISB to RKT Ras Al Khaimah, United Arab Emirates | 1,151 mi | ~2h 58m | Air Arabia | 2×/wk |
| 24 | ISB to MCT Muscat, Oman | 1,117 mi | ~2h 53m | SalamAir | 1/day |
| 25 | ISB to URC Urumqi, China | 1,063 mi | ~2h 47m | China Southern | 3×/wk |