| 1 | LAS to ICN Seoul, South Korea | 6,008 mi | 12h 59m | Korean Air | 1/day |
| 2 | LAS to ZRH Zurich, Switzerland | 5,699 mi | 12h 21m | Edelweiss Air | 2×/wk |
| 3 | LAS to FRA Frankfurt, Germany | 5,569 mi | 12h 4m | Flight Alaska and Condor | 1/day |
| 4 | LAS to CDG Paris, France | 5,429 mi | 11h 47m | Air France | 3×/wk |
| 5 | LAS to AMS Amsterdam, Netherlands | 5,342 mi | 11h 36m | KLM | 1/day |
| 6 | LAS to LHR London, United Kingdom | 5,216 mi | 11h 21m | British Airways and Virgin Atlantic | 3/day |
| 7 | LAS to MAN Manchester, United Kingdom | 5,074 mi | 11h 3m | Virgin Atlantic | 3×/wk |
| 8 | LAS to PTY Panama City, Panama | 2,918 mi | 6h 36m | Copa | 1/day |
| 9 | LAS to LIH Lihue, United States | 2,814 mi | 6h 23m | Southwest Airlines | 1/day |
| 10 | LAS to HNL Honolulu, United States | 2,759 mi | 6h 17m | Alaska Airlines and Southwest Airlines | 6-7/day |
| 11 | LAS to KOA Kailua-Kona, United States | 2,715 mi | 6h 11m | Southwest Airlines | 1/day |
| 12 | LAS to OGG Kahului, United States | 2,692 mi | 6h 8m | Alaska Airlines and Southwest Airlines | 2/day |
| 13 | LAS to BOS Boston, United States | 2,375 mi | 5h 29m | JetBlue Airways and Delta Air Lines | 3-4/day |
| 14 | LAS to ANC Anchorage, United States | 2,301 mi | 5h 20m | Alaska Airlines and Southwest Airlines | 2/day |
| 15 | LAS to BDL Hartford, United States | 2,292 mi | 5h 19m | Breeze | 3×/wk |
| 16 | LAS to SAL Santa Clara, El Salvador | 2,250 mi | 5h 14m | Avianca | 3×/wk |
| 17 | LAS to JFK New York, United States | 2,243 mi | 5h 13m | JetBlue Airways, Delta Air Lines, and American Airlines | 11/day |
| 18 | LAS to YUL Montreal, Canada | 2,234 mi | 5h 12m | Air Canada | 1/day |
| 19 | LAS to EWR Newark, United States | 2,222 mi | 5h 10m | United Airlines and JetBlue Airways | 7-8/day |
| 20 | LAS to PHL Philadelphia, United States | 2,171 mi | 5h 4m | American Airlines and Frontier Airlines | 4-5/day |
| 21 | LAS to MIA Miami, United States | 2,171 mi | 5h 4m | American Airlines and BBQ | 3/day |
| 22 | LAS to FLL Fort Lauderdale, United States | 2,170 mi | 5h 4m | JetBlue Airways | 2-3/day |
| 23 | LAS to ORF Norfolk, United States | 2,149 mi | 5h 1m | Breeze Airways | 2×/wk |
| 24 | LAS to SYR Syracuse, United States | 2,115 mi | 4h 57m | Breeze | 2×/wk |
| 25 | LAS to BWI Baltimore, United States | 2,101 mi | 4h 55m | Southwest Airlines and Delta Air Lines | 4-5/day |