| 1 | LAX to SIN Singapore, Singapore | 8,762 mi | 18h 40m | Singapore Airlines | 1-2/day |
| 2 | LAX to DWC Jebel Ali, United Arab Emirates | 8,350 mi | 17h 49m | Emirates | weekly |
| 3 | LAX to DXB Dubai, United Arab Emirates | 8,326 mi | 17h 46m | Emirates | 1/day |
| 4 | LAX to JED Jeddah, Saudi Arabia | 8,320 mi | 17h 45m | Saudia | 3×/wk |
| 5 | LAX to DOH Doha, Qatar | 8,294 mi | 17h 42m | Qatar Airways | 1/day |
| 6 | LAX to MEL Melbourne, Australia | 7,927 mi | 16h 56m | Qantas, Delta Air Lines, and United Airlines | 1-2/day |
| 7 | LAX to MEB MEB, Australia | 7,926 mi | 16h 56m | Qantas | weekly |
| 8 | LAX to CAI Cairo, Egypt | 7,592 mi | 16h 15m | EgyptAir | 3×/wk |
| 9 | LAX to TLV Tel Aviv, Israel | 7,560 mi | 16h 11m | El Al | 1-2/day |
| 10 | LAX to SYD Sydney, Australia | 7,494 mi | 16h 3m | American Airlines, Delta Air Lines, and Qantas | 4-5/day |
| 11 | LAX to MNL Manila, Philippines | 7,295 mi | 15h 38m | Philippine Airlines | 2-3/day |
| 12 | LAX to HKG Hong Kong, Hong Kong SAR China | 7,248 mi | 15h 32m | Cathay Pacific, United Airlines, and Delta Air Lines | 6/day |
| 13 | LAX to SZX Shenzhen, China | 7,236 mi | 15h 31m | Western Global, Air China, and SF Airlines | 5×/wk |
| 14 | LAX to CAN Guangzhou, China | 7,219 mi | 15h 29m | CSG and China Southern | 1-2/day |
| 15 | LAX to TFU Tianfu, China | 7,192 mi | 15h 25m | Sichuan Airlines | 3×/wk |
| 16 | LAX to BNE Brisbane, Australia | 7,167 mi | 15h 22m | Qantas | 1/day |
| 17 | LAX to XMN Xiamen, China | 6,952 mi | 14h 56m | Xiamen | 3×/wk |
| 18 | LAX to IST Istanbul, Türkiye | 6,837 mi | 14h 41m | Turkish Airlines | 2-3/day |
| 19 | LAX to EHU Ezhou, China | 6,792 mi | 14h 36m | SF Airlines | weekly |
| 20 | LAX to TPE Taipei, Taiwan | 6,787 mi | 14h 35m | EVA Air, China, and Starlux | 6/day |
| 21 | LAX to CTA Catania, Italy | 6,668 mi | 14h 20m | QQE | weekly |
| 22 | LAX to NKG Nanjing, China | 6,566 mi | 14h 8m | Suparna Airlines | weekly |
| 23 | LAX to AKL Auckland, New Zealand | 6,516 mi | 14h 2m | Air New Zealand | 1/day |
| 24 | LAX to WUX Wuxi, China | 6,513 mi | 14h 1m | Masair | 3×/wk |
| 25 | LAX to PVG Shanghai, China | 6,472 mi | 13h 56m | CSG, China Eastern, and United Airlines | 4-5/day |