| 1 | LGA to STS Santa Rosa, United States | 2,575 mi | 5h 54m | American Airlines | weekly |
| 2 | LGA to SAN San Diego, United States | 2,436 mi | 5h 37m | American Airlines | weekly |
| 3 | LGA to SEA Seattle, United States | 2,406 mi | 5h 33m | American Airlines | 3×/wk |
| 4 | LGA to YYC Calgary, Canada | 2,027 mi | 4h 46m | United Airlines | weekly |
| 5 | LGA to DEN Denver, United States | 1,615 mi | 3h 55m | United Airlines, Southwest Airlines, and Delta Air Lines | 13/day |
| 6 | LGA to HOU Houston, United States | 1,426 mi | 3h 32m | Southwest Airlines | 3-4/day |
| 7 | LGA to IAH Houston, United States | 1,415 mi | 3h 30m | United Airlines and Delta Air Lines | 11-12/day |
| 8 | LGA to DFW Dallas, United States | 1,386 mi | 3h 27m | American Airlines, Delta Air Lines, and Frontier Airlines | 17-18/day |
| 9 | LGA to DAL Dallas, United States | 1,379 mi | 3h 26m | Southwest Airlines | 4-5/day |
| 10 | LGA to OKC Oklahoma City, United States | 1,338 mi | 3h 21m | American Airlines and Delta Air Lines | 2-3/day |
| 11 | LGA to TUL Tulsa, United States | 1,228 mi | 3h 7m | American Airlines and Delta Air Lines | 2-3/day |
| 12 | LGA to MSY New Orleans, United States | 1,183 mi | 3h 1m | Delta Air Lines, American Airlines, and Southwest Airlines | 3-4/day |
| 13 | LGA to OMA Omaha, United States | 1,145 mi | 2h 57m | Delta Air Lines and Southwest Airlines | 3-4/day |
| 14 | LGA to XNA Fayetteville/Springdale/Rogers, United States | 1,144 mi | 2h 57m | American Airlines and Delta Air Lines | 3-4/day |
| 15 | LGA to NAS Nassau, Bahamas | 1,107 mi | 2h 52m | Delta Air Lines | weekly |
| 16 | LGA to MCI Kansas City, United States | 1,105 mi | 2h 52m | Delta Air Lines, Southwest Airlines, and American Airlines | 5-6/day |
| 17 | LGA to MIA Miami, United States | 1,099 mi | 2h 51m | American Airlines and Delta Air Lines | 14-15/day |
| 18 | LGA to LIT Little Rock, United States | 1,083 mi | 2h 49m | American Airlines and Delta Air Lines | 1-2/day |
| 19 | LGA to RSW Fort Myers, United States | 1,082 mi | 2h 49m | Delta Air Lines | 1-2/day |
| 20 | LGA to FLL Fort Lauderdale, United States | 1,078 mi | 2h 48m | JetBlue Airways, Delta Air Lines, and American Airlines | 10-11/day |
| 21 | LGA to SRQ Sarasota/Bradenton, United States | 1,048 mi | 2h 45m | Delta Air Lines | 1/day |
| 22 | LGA to PBI West Palm Beach, United States | 1,037 mi | 2h 43m | Delta Air Lines, JetBlue Airways, and American Airlines | 7-8/day |
| 23 | LGA to PNS Pensacola, United States | 1,030 mi | 2h 43m | Delta Air Lines | 1/day |
| 24 | LGA to DSM Des Moines, United States | 1,029 mi | 2h 42m | Delta Air Lines and American Airlines | 1-2/day |
| 25 | LGA to MSP Minneapolis, United States | 1,018 mi | 2h 41m | Delta Air Lines | 4-5/day |