| 1 | LIS to ICN Seoul, South Korea | 6,460 mi | 13h 55m | Korean Air | 3×/wk |
| 2 | LIS to LAX Los Angeles, United States | 5,677 mi | 12h 18m | TAP Air Portugal | 1/day |
| 3 | LIS to SFO San Francisco, United States | 5,668 mi | 12h 17m | TAP Air Portugal | 1/day |
| 4 | LIS to POA Porto Alegre, Brazil | 5,468 mi | 11h 52m | TAP Air Portugal | 3×/wk |
| 5 | LIS to FLN Florianopolis, Brazil | 5,249 mi | 11h 25m | TAP Air Portugal | 3×/wk |
| 6 | LIS to MPM Maputo, Mozambique | 5,220 mi | 11h 21m | TAP Air Portugal | 3×/wk |
| 7 | LIS to GRU Sao Paulo, Brazil | 4,931 mi | 10h 45m | TAP Air Portugal and LATAM Airlines | 3-4/day |
| 8 | LIS to VCP Campinas, Brazil | 4,926 mi | 10h 45m | Azul Airlines | 1-2/day |
| 9 | LIS to GIG Rio de Janeiro, Brazil | 4,794 mi | 10h 28m | TAP Air Portugal | 1-2/day |
| 10 | LIS to CUN Cancun, Mexico | 4,678 mi | 10h 14m | Orbest S.A. and World2fly Portugal | weekly |
| 11 | LIS to CNF Belo Horizonte, Brazil | 4,622 mi | 10h 7m | TAP Air Portugal | 1/day |
| 12 | LIS to BSB Brasilia, Brazil | 4,532 mi | 9h 56m | TAP Air Portugal | 1/day |
| 13 | LIS to MIA Miami, United States | 4,149 mi | 9h 9m | TAP Air Portugal | 1-2/day |
| 14 | LIS to CCS Caracas, Venezuela | 4,040 mi | 8h 55m | TAP Air Portugal | 2×/wk |
| 15 | LIS to SSA Salvador, Brazil | 4,038 mi | 8h 55m | TAP Air Portugal | 1/day |
| 16 | LIS to ORD Chicago, United States | 3,999 mi | 8h 50m | TAP Air Portugal | 1/day |
| 17 | LIS to DXB Dubai, United Arab Emirates | 3,814 mi | 8h 27m | Emirates | 2/day |
| 18 | LIS to AUH Abu Dhabi, United Arab Emirates | 3,805 mi | 8h 26m | Etihad Airways | 3×/wk |
| 19 | LIS to PUJ Punta Cana, Dominican Republic | 3,781 mi | 8h 23m | Orbest S.A. and World2fly Portugal | 3×/wk |
| 20 | LIS to BEL Belem, Brazil | 3,732 mi | 8h 17m | TAP Air Portugal | 1/day |
| 21 | LIS to REC Recife, Brazil | 3,640 mi | 8h 6m | TAP Air Portugal | 1-2/day |
| 22 | LIS to NBJ Luanda, Angola | 3,611 mi | 8h 2m | TAAG and TAP Air Portugal | 2-3/day |
| 23 | LIS to IAD Washington, United States | 3,583 mi | 7h 59m | TAP Air Portugal and United Airlines | 2-3/day |
| 24 | LIS to YYZ Toronto, Canada | 3,567 mi | 7h 57m | TAP Air Portugal, Air Canada, and Air Transat | 3-4/day |
| 25 | LIS to NAT São Gonçalo do Amarante, Brazil | 3,506 mi | 7h 49m | TAP Air Portugal | 1/day |