| 1 | LOS to ATL Atlanta, United States | 5,838 mi | ~12h 38m | Delta Air Lines | 1/day |
| 2 | LOS to IAD Washington, United States | 5,438 mi | ~11h 48m | United Airlines | 3×/wk |
| 3 | LOS to DXB Dubai, United Arab Emirates | 3,664 mi | ~8h 9m | Emirates | 1/day |
| 4 | LOS to DOH Doha, Qatar | 3,435 mi | ~7h 40m | Qatar Airways | 2/day |
| 5 | LOS to AMS Amsterdam, Netherlands | 3,161 mi | ~7h 6m | KLM | 1/day |
| 6 | LOS to LHR London, United Kingdom | 3,109 mi | ~7h | British Airways and Virgin Atlantic | 2/day |
| 7 | LOS to LGW London, United Kingdom | 3,086 mi | ~6h 57m | Air Peace | 1/day |
| 8 | LOS to FRA Frankfurt, Germany | 3,017 mi | ~6h 49m | Lufthansa | 1/day |
| 9 | LOS to CDG Paris, France | 2,932 mi | ~6h 38m | Air France | 1/day |
| 10 | LOS to IST Istanbul, Türkiye | 2,862 mi | ~6h 29m | Turkish Airlines | 3×/wk |
| 11 | LOS to JNB Johannesburg, South Africa | 2,811 mi | ~6h 23m | South African Airways | 1/day |
| 12 | LOS to BEY Beirut, Lebanon | 2,786 mi | ~6h 20m | Middle East Airlines | 2×/wk |
| 13 | LOS to CAI Cairo, Egypt | 2,443 mi | ~5h 37m | EgyptAir | 1/day |
| 14 | LOS to ADD Addis Ababa, Ethiopia | 2,433 mi | ~5h 36m | Ethiopian Airlines | 1-2/day |
| 15 | LOS to NBO Nairobi, Kenya | 2,381 mi | ~5h 30m | Kenya Airways | 1/day |
| 16 | LOS to CMN Casablanca, Morocco | 1,979 mi | ~4h 40m | Royal Air Maroc | 1-2/day |
| 17 | LOS to KGL Kigali, Rwanda | 1,942 mi | ~4h 35m | RwandAir | 1/day |
| 18 | LOS to BJL Banjul, Gambia | 1,436 mi | ~3h 33m | Anisec | 2×/wk |
| 19 | LOS to NBJ Luanda, Angola | 1,287 mi | ~3h 14m | TAAG | 1/day |
| 20 | LOS to LBV Libreville, Gabon | 596 mi | ~1h 49m | Air Cote D'Ivoire, ASKY, and Afrijet | 1-2/day |
| 21 | LOS to KAN Kano, Nigeria | 518 mi | ~1h 39m | Air Peace, Business Aviation Asia, and Real Tonga | 3/day |
| 22 | LOS to ABJ Abidjan, Côte d’Ivoire | 506 mi | ~1h 38m | Air Cote D'Ivoire, Air Peace, and Middle East Airlines | 1-2/day |
| 23 | LOS to SKO Sokoto, Nigeria | 456 mi | ~1h 32m | Business Aviation Asia | 1/day |
| 24 | LOS to SSG Malabo, Equatorial Guinea | 419 mi | ~1h 27m | Lufthansa | 1/day |
| 25 | LOS to KAD Kaduna, Nigeria | 394 mi | ~1h 24m | Real Tonga | 1/day |