| 1 | LUX to TPE Taipei, Taiwan | 5,936 mi | ~12h 50m | China Airlines | weekly |
| 2 | LUX to CGO Zhengzhou, China | 5,149 mi | ~11h 12m | China Southern | weekly |
| 3 | LUX to SID Espargos, Cape Verde | 2,779 mi | ~6h 19m | Luxair | weekly |
| 4 | LUX to RMF Marsa Alam, Egypt | 2,242 mi | ~5h 13m | Luxair | weekly |
| 5 | LUX to HRG Hurghada, Egypt | 2,123 mi | ~4h 58m | Luxair | weekly |
| 6 | LUX to TFS Tenerife Island, Spain | 1,900 mi | ~4h 30m | Luxair | 3×/wk |
| 7 | LUX to LPA Gran Canaria Island, Spain | 1,868 mi | ~4h 26m | Luxair | 2×/wk |
| 8 | LUX to FUE Fuerteventura Island, Spain | 1,789 mi | ~4h 16m | Luxair | 2×/wk |
| 9 | LUX to ACE Lanzarote Island, Spain | 1,752 mi | ~4h 12m | Luxair | 2×/wk |
| 10 | LUX to FNC Funchal, Portugal | 1,646 mi | ~3h 59m | Luxair | 2×/wk |
| 11 | LUX to PXO Porto Santo, Portugal | 1,611 mi | ~3h 54m | Luxair | weekly |
| 12 | LUX to AGA Agadir, Morocco | 1,546 mi | ~3h 46m | Luxair | weekly |
| 13 | LUX to AYT Antalya, Türkiye | 1,503 mi | ~3h 41m | Luxair | 3×/wk |
| 14 | LUX to RHO Rhodes, Greece | 1,419 mi | ~3h 31m | Luxair | 3×/wk |
| 15 | LUX to HER Heraklion, Greece | 1,366 mi | ~3h 24m | Luxair | 3×/wk |
| 16 | LUX to KGS Kos Island, Greece | 1,361 mi | ~3h 24m | Luxair | weekly |
| 17 | LUX to CHQ Souda, Greece | 1,320 mi | ~3h 18m | Luxair | 2×/wk |
| 18 | LUX to ADB Izmir, Türkiye | 1,291 mi | ~3h 15m | Luxair | weekly |
| 19 | LUX to IST Istanbul, Türkiye | 1,227 mi | ~3h 7m | Turkish Airlines | 1-2/day |
| 20 | LUX to ATH Athens, Greece | 1,185 mi | ~3h 2m | Aegean Airlines | 3×/wk |
| 21 | LUX to BOJ Burgas, Bulgaria | 1,125 mi | ~2h 54m | Luxair | 2×/wk |
| 22 | LUX to VAR Varna, Bulgaria | 1,115 mi | ~2h 53m | Luxair | 2×/wk |
| 23 | LUX to FAO Faro, Portugal | 1,106 mi | ~2h 52m | Luxair and Ryanair | 1-2/day |
| 24 | LUX to DJE Djerba, Tunisia | 1,097 mi | ~2h 51m | Luxair | 1/day |
| 25 | LUX to ZTH Zakynthos Island, Greece | 1,088 mi | ~2h 50m | Luxair | weekly |