| Mexico City (MEX) Licenciado Benito Juarez International Airport | Mexico | 5,633 mi | 12h 12m | Iberia and Aeromexico | 5-6/day |
| New York (JFK) John F Kennedy International Airport | United States | 3,580 mi | 7h 58m | Iberia, American Airlines, and Delta Air Lines | 4-5/day |
| Miami (MIA) Miami International Airport | United States | 4,416 mi | 9h 42m | Iberia, Air Europa, and American Airlines | 3-4/day |
| Boston (BOS) General Edward Lawrence Logan International Airport | United States | 3,401 mi | 7h 36m | Iberia, Delta Air Lines, and JetBlue Airways | 3-4/day |
| Santo Domingo (SDQ) Las Americas International Airport | Dominican Republic | 4,157 mi | 9h 10m | Iberia, Air Europa, and WFL | 2-3/day |
| Washington (IAD) Washington Dulles International Airport | United States | 3,806 mi | 8h 26m | United Airlines and Iberia | 2-3/day |
| Dallas (DFW) Dallas-Fort Worth International Airport | United States | 4,954 mi | 10h 48m | American Airlines and Iberia | 2/day |
| Chicago (ORD) Chicago O'Hare International Airport | United States | 4,191 mi | 9h 14m | Iberia and American Airlines | 1-2/day |
| Newark (EWR) Newark Liberty International Airport | United States | 3,597 mi | 8h | United Airlines and Iberia | 1-2/day |
| San Jose (SJO) Juan Santamaria International Airport | Costa Rica | 5,281 mi | 11h 29m | Iberia and Evelop | 1-2/day |
| Panama City (PTY) Tocumen International Airport | Panama | 5,069 mi | 11h 2m | Air Europa and Iberia | 1-2/day |
| San Juan (SJU) Luis Munoz Marin International Airport | United States | 3,964 mi | 8h 46m | Iberia | 1-2/day |
| Monterrey (MTY) General Mariano Escobedo International Airport | Mexico | 5,403 mi | 11h 44m | Aeromexico and Iberia | 1-2/day |
| Toronto (YYZ) Toronto Pearson International Airport | Canada | 3,765 mi | 8h 21m | Air Canada and Iberia | 1-2/day |
| Atlanta (ATL) Hartsfield/Jackson Atlanta International Airport | United States | 4,325 mi | 9h 30m | Delta Air Lines | 1-2/day |
| Montreal (YUL) Montréal-Pierre Elliott Trudeau International Airport | Canada | 3,449 mi | 7h 42m | Air Canada and Air Transat | 1-2/day |
| Los Angeles (LAX) Los Angeles International Airport | United States | 5,832 mi | 12h 37m | Iberia | 1/day |
| Guatemala City (GUA) La Aurora Airport | Guatemala | 5,411 mi | 11h 45m | Iberia | 1/day |
| Charlotte (CLT) Charlotte/Douglas International Airport | United States | 4,099 mi | 9h 2m | American Airlines | 1/day |
| Punta Cana (PUJ) Punta Cana International Airport | Dominican Republic | 4,082 mi | 9h | Air Europa, Evelop, and WFL | 7×/wk |
| Philadelphia (PHL) Philadelphia International Airport | United States | 3,672 mi | 8h 10m | American Airlines | 1/day |
| Guadalajara (GDL) Don Miguel Hidalgo Y Costilla International Airport | Mexico | 5,794 mi | 12h 32m | Aeromexico | 1/day |
| Cancun (CUN) Cancun International Airport | Mexico | 4,947 mi | 10h 47m | Air Europa and Evelop | 1/day |
| Havana (HAV) Jose Marti International Airport | Cuba | 4,636 mi | 10h 9m | Air Europa and Air China | 5×/wk |
| San Francisco (SFO) San Francisco International Airport | United States | 5,798 mi | 12h 33m | Iberia | 3×/wk |
| Queretaro (QRO) Queretaro Intercontinental Airport | Mexico | 5,636 mi | 12h 13m | Evelop | 3×/wk |
| La Mesa (SAP) Ramon Villeda Morales International Airport | Honduras | 5,238 mi | 11h 23m | Air Europa | 3×/wk |
| Orlando (MCO) Orlando International Airport | United States | 4,366 mi | 9h 35m | Iberia | 3×/wk |
| Halifax (YHZ) Halifax Robert L. Stanfield International Airport | Canada | 2,990 mi | 6h 45m | WestJet | 3×/wk |
| Santa Clara (SAL) El Salvador International Airport | El Salvador | 5,384 mi | 11h 42m | Avianca | weekly |
| Comayagua (XPL) Comayagua-Palmerola International Airport | Honduras | 5,269 mi | 11h 27m | Evelop | weekly |
| Santiago (STI) Cibao International Airport | Dominican Republic | 4,166 mi | 9h 11m | Air Europa | weekly |