| 1 | MAF to LAS Las Vegas, United States | 794 mi | ~2h 13m | Southwest Airlines | 1/day |
| 2 | MAF to PHX Phoenix, United States | 579 mi | ~1h 47m | United Airlines | 1/day |
| 3 | MAF to DEN Denver, United States | 564 mi | ~1h 45m | United Airlines and Southwest Airlines | 5-6/day |
| 4 | MAF to BVO Bartlesville, United States | 485 mi | ~1h 35m | ConocoPhillips | weekly |
| 5 | MAF to MFE Mc Allen, United States | 465 mi | ~1h 33m | Sun Country Airlines | weekly |
| 6 | MAF to HOU Houston, United States | 440 mi | ~1h 30m | Southwest Airlines and Saga Airlines | 4/day |
| 7 | MAF to IAH Houston, United States | 428 mi | ~1h 28m | United Airlines and ConocoPhillips | 6-7/day |
| 8 | MAF to DAL Dallas, United States | 318 mi | ~1h 14m | Southwest Airlines | 4/day |
| 9 | MAF to DFW Dallas, United States | 308 mi | ~1h 13m | American Airlines and United Airlines | 8-9/day |
| 10 | MAF to AUS Austin, United States | 294 mi | ~1h 11m | Southwest Airlines | 1/day |
| 11 | MAF to SAT San Antonio, United States | 277 mi | ~1h 9m | United Airlines | weekly |
| 12 | MAF to CNM Carlsbad, United States | 124 mi | ~50m | ConocoPhillips | weekly |
| 13 | MAF to LBB Lubbock, United States | 121 mi | ~50m | Empire Airlines and Baron Aviation Services | 1/day |