| 1 | STT to DFW Dallas, United States | 2,224 mi | ~5h 10m | American Airlines | 1/day |
| 2 | STT to ORD Chicago, United States | 2,118 mi | ~4h 57m | United Airlines | weekly |
| 3 | STT to IAH Houston, United States | 2,068 mi | ~4h 51m | United Airlines | 1/day |
| 4 | STT to EWR Newark, United States | 1,638 mi | ~3h 58m | United Airlines | 2×/wk |
| 5 | STT to JFK New York, United States | 1,627 mi | ~3h 56m | American Airlines and Delta Air Lines | 2/day |
| 6 | STT to IAD Washington, United States | 1,609 mi | ~3h 54m | United Airlines | 1/day |
| 7 | STT to PHL Philadelphia, United States | 1,609 mi | ~3h 54m | American Airlines | weekly |
| 8 | STT to BWI Baltimore, United States | 1,601 mi | ~3h 53m | Southwest Airlines | 3×/wk |
| 9 | STT to ATL Atlanta, United States | 1,600 mi | ~3h 53m | Delta Air Lines | 2-3/day |
| 10 | STT to CLT Charlotte, United States | 1,522 mi | ~3h 43m | American Airlines | 2/day |
| 11 | STT to ORF Norfolk, United States | 1,452 mi | ~3h 35m | United Airlines | weekly |
| 12 | STT to MCO Orlando, United States | 1,247 mi | ~3h 9m | Southwest Airlines | 1/day |
| 13 | STT to MIA Miami, United States | 1,107 mi | ~2h 52m | American Airlines | 2-3/day |
| 14 | STT to DOM Marigot, Dominica | 310 mi | ~1h 13m | American Airlines | 3×/wk |
| 15 | STT to SDQ Santo Domingo, Dominican Republic | 308 mi | ~1h 13m | Sky High Aviation | weekly |
| 16 | STT to ANU St. George, Antigua & Barbuda | 225 mi | ~1h 3m | Naysa | 2×/wk |
| 17 | STT to NEV Charlestown, St. Kitts & Nevis | 175 mi | ~57m | United Airlines | 1/day |
| 18 | STT to SKB Basseterre, St. Kitts & Nevis | 164 mi | ~55m | United Airlines | 1/day |
| 19 | STT to AXA The Valley, Anguilla | 126 mi | ~51m | United Airlines and Naysa | 1-2/day |
| 20 | STT to SJU San Juan, United States | 68 mi | ~43m | United Airlines, Air Flamenco, and JetBlue Airways | 8-9/day |
| 21 | STT to STX Christiansted, United States | 45 mi | ~41m | United Airlines | 7-8/day |
| 22 | STT to EIS Road Town, British Virgin Islands | 29 mi | ~39m | United Airlines | 2-3/day |