| Monterrey (MTY) General Mariano Escobedo International Airport | Mexico | 443 mi | 1h 30m | Aeromexico, VivaAerobus, and Volaris | 27-28/day |
| Cancun (CUN) Cancun International Airport | Mexico | 798 mi | 2h 14m | Aeromexico, VivaAerobus, and Volaris | 25-26/day |
| Guadalajara (GDL) Don Miguel Hidalgo Y Costilla International Airport | Mexico | 285 mi | 1h 10m | Aeromexico, Volaris, and VivaAerobus | 20-21/day |
| Tijuana (TIJ) General Abelardo L. Rodriguez International Airport | Mexico | 1,430 mi | 3h 32m | Aeromexico, Volaris, and VivaAerobus | 16-17/day |
| Merida (MID) Licenciado Manuel Crescencio Rejon Int Airport | Mexico | 619 mi | 1h 52m | Aeromexico, VivaAerobus, and Volaris | 12-13/day |
| Houston (IAH) George Bush Intcntl/Houston Airport | United States | 765 mi | 2h 10m | United Airlines, Aeromexico, and VivaAerobus | 9-10/day |
| Los Angeles (LAX) Los Angeles International Airport | United States | 1,553 mi | 3h 47m | Aeromexico, Volaris, and VivaAerobus | 8-9/day |
| Puerto Vallarta (PVR) Licenciado Gustavo Diaz Ordaz International Airport | Mexico | 410 mi | 1h 26m | Aeromexico, Volaris, and VivaAerobus | 7-8/day |
| Miami (MIA) Miami International Airport | United States | 1,274 mi | 3h 13m | American Airlines, Aeromexico, and Volaris | 7-8/day |
| Chicago (ORD) Chicago O'Hare International Airport | United States | 1,689 mi | 4h 4m | Aeromexico, Volaris, and American Airlines | 7/day |
| Panama City (PTY) Tocumen International Airport | Panama | 1,498 mi | 3h 40m | Copa and Aeromexico | 7/day |
| Hermosillo (HMO) General Ignacio P. Garcia International Airport | Mexico | 1,006 mi | 2h 40m | Aeromexico, VivaAerobus, and Volaris | 6-7/day |
| Chihuahua (CUU) General Roberto Fierro Villalobos International Airport | Mexico | 774 mi | 2h 11m | Aeromexico, VivaAerobus, and Volaris | 6-7/day |
| Tuxtla Gutierrez (TGZ) Angel Albino Corzo International Airport | Mexico | 444 mi | 1h 30m | Aeromexico, Volaris, and VivaAerobus | 6-7/day |
| Villahermosa (VSA) Carlos Rovirosa Perez International Airport | Mexico | 421 mi | 1h 27m | Aeromexico, VivaAerobus, and Volaris | 6/day |
| Dallas (DFW) Dallas-Fort Worth International Airport | United States | 939 mi | 2h 31m | American Airlines, Aeromexico, and Volaris | 5-6/day |
| San Jose del Cabo (SJD) Los Cabos International Airport | Mexico | 732 mi | 2h 6m | Aeromexico, Volaris, and VivaAerobus | 5-6/day |
| Ciudad Juarez (CJS) Abraham Gonzalez International Airport | Mexico | 959 mi | 2h 34m | Aeromexico, VivaAerobus, and Volaris | 5-6/day |
| Atlanta (ATL) Hartsfield/Jackson Atlanta International Airport | United States | 1,332 mi | 3h 20m | Delta Air Lines | 5/day |
| San Francisco (SFO) San Francisco International Airport | United States | 1,882 mi | 4h 28m | United Airlines and Aeromexico | 4-5/day |
| San Luis Potosi (SLP) Ponciano Arriaga International Airport | Mexico | 229 mi | 1h 3m | Aeromexico | 4-5/day |
| New York (JFK) John F Kennedy International Airport | United States | 2,091 mi | 4h 54m | Aeromexico, American Airlines, and Delta Air Lines | 4-5/day |
| Torreon (TRC) Francisco Sarabia International Airport | Mexico | 506 mi | 1h 38m | Aeromexico and VivaAerobus | 4-5/day |
| Silao (BJX) Del Bajio International Airport | Mexico | 190 mi | 58m | Aeromexico | 4-5/day |
| Aguascalientes (AGU) Jesus Teran International Airport | Mexico | 262 mi | 1h 7m | Aeromexico | 4-5/day |
| San Jose (SJO) Juan Santamaria International Airport | Costa Rica | 1,187 mi | 3h 2m | Aeromexico, Avianca, and Volaris Costa Rica | 4/day |
| Tampico (TAM) General Francisco Javier Mina International Airport | Mexico | 212 mi | 1h 1m | Aeromexico | 4/day |
| Guatemala City (GUA) La Aurora Airport | Guatemala | 656 mi | 1h 56m | Aeromexico, Volaris, and Volaris Costa Rica | 3-4/day |
| Orlando (MCO) Orlando International Airport | United States | 1,280 mi | 3h 13m | Aeromexico and Volaris | 3-4/day |
| Culiacan (CUL) Federal de Bachigualato International Airport | Mexico | 652 mi | 1h 56m | Aeromexico and Volaris | 3-4/day |
| Puerto Escondido (PXM) Puerto Escondido International Airport | Mexico | 278 mi | 1h 9m | VivaAerobus, Volaris, and Aeromexico | 3-4/day |
| Mazatlan (MZT) General Rafael Buelna International Airport | Mexico | 530 mi | 1h 41m | Aeromexico, VivaAerobus, and Volaris | 3-4/day |
| Toronto (YYZ) Toronto Pearson International Airport | Canada | 2,017 mi | 4h 45m | Air Canada, Aeromexico, and Flair | 3-4/day |
| La Paz (LAP) Manuel Marquez de Leon International Airport | Mexico | 792 mi | 2h 13m | Aeromexico and Volaris | 3-4/day |
| Newark (EWR) Newark Liberty International Airport | United States | 2,077 mi | 4h 52m | United Airlines and Aeromexico | 3/day |
| Las Vegas (LAS) Harry Reid International Airport | United States | 1,508 mi | 3h 42m | Aeromexico, VivaAerobus, and Volaris | 3/day |
| Denver (DEN) Denver International Airport | United States | 1,450 mi | 3h 34m | Aeromexico, United Airlines, and Volaris | 3/day |
| San Antonio (SAT) San Antonio International Airport | United States | 699 mi | 2h 1m | Aeromexico, VivaAerobus, and Volaris | 3/day |
| Oaxaca (OAX) Xoxocotlan International Airport | Mexico | 228 mi | 1h 3m | Aeromexico, VivaAerobus, and Volaris | 3/day |
| Acapulco (ACA) General Juan N Alvarez International Airport | Mexico | 190 mi | 59m | Aeromexico and Volaris | 3/day |
| Queretaro (QRO) Queretaro Intercontinental Airport | Mexico | 109 mi | 48m | Aeromexico | 3/day |
| Mexicali (MXL) General Rodolfo Sanchez Taboada International Airport | Mexico | 1,353 mi | 3h 22m | Aeromexico and Volaris | 2-3/day |
| Chetumal (CTM) Chetumal International Airport | Mexico | 705 mi | 2h 2m | VivaAerobus, Volaris, and Aeromexico | 2-3/day |
| Durango (DGO) General Guadalupe Victoria International Airport | Mexico | 477 mi | 1h 34m | Aeromexico | 2-3/day |
| Ixtapa (ZIH) Ixtapa Zihuatanejo International Airport | Mexico | 201 mi | 1h | Aeromexico and Volaris | 2-3/day |
| Los Mochis (LMM) Valle del Fuerte International Airport | Mexico | 770 mi | 2h 10m | Aeromexico and Volaris | 2-3/day |
| Huatulco (HUX) Bahias de Huatulco International Airport | Mexico | 313 mi | 1h 14m | VivaAerobus, Volaris, and Aeromexico | 2-3/day |
| Vancouver (YVR) Vancouver International Airport | Canada | 2,451 mi | 5h 38m | Aeromexico, Air Canada, and Flair | 2-3/day |
| Santa Clara (SAL) El Salvador International Airport | El Salvador | 782 mi | 2h 12m | Avianca, Aeromexico, and Vuela El Salvador | 2-3/day |
| Tapachula (TAP) Tapachula International Airport | Mexico | 546 mi | 1h 43m | Aeromexico and Volaris | 2-3/day |
| Montreal (YUL) Montréal-Pierre Elliott Trudeau International Airport | Canada | 2,307 mi | 5h 21m | Aeromexico and Air Canada | 2/day |
| Washington (IAD) Washington Dulles International Airport | United States | 1,865 mi | 4h 26m | Aeromexico and United Airlines | 2/day |
| Cozumel (CZM) Cozumel International Airport | Mexico | 792 mi | 2h 13m | Aeromexico and Volaris | 2/day |
| Reynosa (REX) General Lucio Blanco International Airport | Mexico | 457 mi | 1h 32m | Aeromexico and VivaAerobus | 2/day |
| Campeche (CPE) Ingeniero Alberto Acuna Ongay International Airport | Mexico | 558 mi | 1h 44m | Aeromexico | 1-2/day |
| Manzanillo (ZLO) Playa De Oro International Airport | Mexico | 358 mi | 1h 19m | Aeromexico | 1-2/day |
| Zacatecas (ZCL) General Leobardo C. Ruiz International Airport | Mexico | 334 mi | 1h 16m | Aeromexico | 1-2/day |
| Veracruz (VER) General Heriberto Jara International Airport | Mexico | 189 mi | 58m | VivaAerobus and Aeromexico | 1-2/day |
| Ciudad del Carmen (CME) Ciudad del Carmen International Airport | Mexico | 478 mi | 1h 34m | Aeromexico | 1-2/day |
| Ciudad Obregon (CEN) Ciudad Obregon International Airport | Mexico | 875 mi | 2h 23m | Aeromexico | 1-2/day |
| Seattle (SEA) Seattle-Tacoma International Airport | United States | 2,335 mi | 5h 24m | Aeromexico | 1/day |
| Boston (BOS) General Edward Lawrence Logan International Airport | United States | 2,277 mi | 5h 17m | Aeromexico | 1/day |
| Punta Cana (PUJ) Punta Cana International Airport | Dominican Republic | 2,004 mi | 4h 43m | Aeromexico | 1/day |
| Philadelphia (PHL) Philadelphia International Airport | United States | 1,998 mi | 4h 42m | Aeromexico | 1/day |
| Santo Domingo (SDQ) Las Americas International Airport | Dominican Republic | 1,921 mi | 4h 33m | Aeromexico | 1/day |
| Oakland (OAK) Oakland San Francisco Bay Airport | United States | 1,879 mi | 4h 28m | Volaris | 1/day |
| Detroit (DTW) Detroit Metro Wayne County Airport | United States | 1,822 mi | 4h 21m | Delta Air Lines | 1/day |
| Minneapolis (MSP) Minneapolis-St Paul International/Wold-Chamberlain Airport | United States | 1,790 mi | 4h 17m | Delta Air Lines | 1/day |
| Raleigh (RDU) Raleigh-Durham International Airport | United States | 1,676 mi | 4h 2m | Aeromexico | 1/day |
| Salt Lake City (SLC) Salt Lake City International Airport | United States | 1,660 mi | 4h 1m | Delta Air Lines | 1/day |
| Charlotte (CLT) Charlotte/Douglas International Airport | United States | 1,552 mi | 3h 47m | American Airlines | 1/day |
| Phoenix (PHX) Phoenix Sky Harbor International Airport | United States | 1,253 mi | 3h 10m | Aeromexico | 1/day |
| Tampa (TPA) Tampa International Airport | United States | 1,199 mi | 3h 3m | Aeromexico | 1/day |
| Havana (HAV) Jose Marti International Airport | Cuba | 1,100 mi | 2h 51m | Aeromexico | 1/day |
| Austin (AUS) Austin-Bergstrom International Airport | United States | 748 mi | 2h 8m | Aeromexico | 1/day |
| Tulum (TQO) Felipe Carrillo Puerto International Airport | Mexico | 743 mi | 2h 7m | Aeromexico | 1/day |
| Morelia (MLM) General Francisco J. Mujica International Airport | Mexico | 130 mi | 51m | Aeromexico | 1/day |
| Tepic (TPQ) Amado Nervo National Airport | Mexico | 398 mi | 1h 24m | Aeromexico | 1/day |
| Calgary (YYC) Calgary International Airport | Canada | 2,335 mi | 5h 24m | WestJet | 1/day |
| Comayagua (XPL) Comayagua-Palmerola International Airport | Honduras | 833 mi | 2h 18m | Aeromexico | 1/day |
| La Mesa (SAP) Ramon Villeda Morales International Airport | Honduras | 784 mi | 2h 12m | Aeromexico | 1/day |
| Nuevo Laredo (NLD) Quetzalcoatl International Airport | Mexico | 554 mi | 1h 44m | Aeromexico | 1/day |
| Managua (MGA) Augusto C. Sandino (Managua) International Airport | Nicaragua | 994 mi | 2h 38m | Aeromexico | 3×/wk |
| Matamoros (MAM) General Servando Canales International Airport | Mexico | 449 mi | 1h 31m | Aeromexico | 3×/wk |
| San Diego (SDM) Brown Field Municipal Airport | United States | 1,431 mi | 3h 32m | Volaris | weekly |