| Houston (IAH) George Bush Intcntl/Houston Airport | United States | 765 mi | 2h 10m | United Airlines, Aeromexico, and VivaAerobus | 9-10/day |
| Los Angeles (LAX) Los Angeles International Airport | United States | 1,553 mi | 3h 47m | Aeromexico, Volaris, and VivaAerobus | 8-9/day |
| Miami (MIA) Miami International Airport | United States | 1,274 mi | 3h 13m | American Airlines, Aeromexico, and Volaris | 7-8/day |
| Chicago (ORD) Chicago O'Hare International Airport | United States | 1,689 mi | 4h 4m | Aeromexico, Volaris, and American Airlines | 7/day |
| Dallas (DFW) Dallas-Fort Worth International Airport | United States | 939 mi | 2h 31m | American Airlines, Aeromexico, and Volaris | 5-6/day |
| Atlanta (ATL) Hartsfield/Jackson Atlanta International Airport | United States | 1,332 mi | 3h 20m | Delta Air Lines | 5/day |
| San Francisco (SFO) San Francisco International Airport | United States | 1,882 mi | 4h 28m | United Airlines and Aeromexico | 4-5/day |
| New York (JFK) John F Kennedy International Airport | United States | 2,091 mi | 4h 54m | Aeromexico, American Airlines, and Delta Air Lines | 4-5/day |
| Orlando (MCO) Orlando International Airport | United States | 1,280 mi | 3h 13m | Aeromexico and Volaris | 3-4/day |
| Newark (EWR) Newark Liberty International Airport | United States | 2,077 mi | 4h 52m | United Airlines and Aeromexico | 3/day |
| Las Vegas (LAS) Harry Reid International Airport | United States | 1,508 mi | 3h 42m | Aeromexico, VivaAerobus, and Volaris | 3/day |
| Denver (DEN) Denver International Airport | United States | 1,450 mi | 3h 34m | Aeromexico, United Airlines, and Volaris | 3/day |
| San Antonio (SAT) San Antonio International Airport | United States | 699 mi | 2h 1m | Aeromexico, VivaAerobus, and Volaris | 3/day |
| Washington (IAD) Washington Dulles International Airport | United States | 1,865 mi | 4h 26m | Aeromexico and United Airlines | 2/day |
| Seattle (SEA) Seattle-Tacoma International Airport | United States | 2,335 mi | 5h 24m | Aeromexico | 1/day |
| Boston (BOS) General Edward Lawrence Logan International Airport | United States | 2,277 mi | 5h 17m | Aeromexico | 1/day |
| Philadelphia (PHL) Philadelphia International Airport | United States | 1,998 mi | 4h 42m | Aeromexico | 1/day |
| Oakland (OAK) Oakland San Francisco Bay Airport | United States | 1,879 mi | 4h 28m | Volaris | 1/day |
| Detroit (DTW) Detroit Metro Wayne County Airport | United States | 1,822 mi | 4h 21m | Delta Air Lines | 1/day |
| Minneapolis (MSP) Minneapolis-St Paul International/Wold-Chamberlain Airport | United States | 1,790 mi | 4h 17m | Delta Air Lines | 1/day |
| Raleigh (RDU) Raleigh-Durham International Airport | United States | 1,676 mi | 4h 2m | Aeromexico | 1/day |
| Salt Lake City (SLC) Salt Lake City International Airport | United States | 1,660 mi | 4h 1m | Delta Air Lines | 1/day |
| Charlotte (CLT) Charlotte/Douglas International Airport | United States | 1,552 mi | 3h 47m | American Airlines | 1/day |
| Phoenix (PHX) Phoenix Sky Harbor International Airport | United States | 1,253 mi | 3h 10m | Aeromexico | 1/day |
| Tampa (TPA) Tampa International Airport | United States | 1,199 mi | 3h 3m | Aeromexico | 1/day |
| Austin (AUS) Austin-Bergstrom International Airport | United States | 748 mi | 2h 8m | Aeromexico | 1/day |
| San Diego (SDM) Brown Field Municipal Airport | United States | 1,431 mi | 3h 32m | Volaris | weekly |